先天性风疹综合征指孕妇在妊娠早期（尤其是妊娠首三个月）感染风疹病毒后，病毒经胎盘传播给胎儿所引起的先天性畸形综合征，可导致流产、胎儿死亡、死产或存活婴儿出现多器官先天缺陷[2]。CRS主要表现为听力障碍、心脏畸形和眼部缺陷三大类，源于母体在末次月经后0–20周内的风疹感染[1]。
疾病概览
先天性风疹综合征
Congenital rubella syndrome
有证据支持的资料英文 3/7 个适用章节 · 中文 3/7 个适用章节更新于 2026年9月3日
先天性风疹综合征（CRS）在风疹疫苗覆盖率不足的人群中持续导致残疾，表现为听力、心脏和眼部等多器官先天缺陷[1]。全球公共卫生合作已通过提高风疹疫苗接种覆盖率大幅减少了CRS所致出生缺陷[1]。系统综述显示，每例CRS患者可造成约19–39个伤残调整生命年（DALYs），反映了该病对患儿终身健康和经济负担的严重影响[1]。
阅读完整临床与流行病学资料4
CRS患儿的临床表现以听力损害、心脏畸形和眼部缺陷三大类为主要特征[1]。系统综述汇总了66个研究队列中至少20例CRS患儿的临床数据，评估了这些缺陷出现的频率、严重程度及组合方式[1]。研究还根据全球疾病负担的伤残权重估算了不同收入水平国家每例CRS患者的DALYs，范围约为19–39个，反映出该综合征对患儿的终生影响[1]。
风疹及CRS的发病与疫苗覆盖率密切相关，在未实现广泛疫苗接种的地区仍有传播和先天畸形的发生[3]。WHO数据显示，全球风疹病例报告受监测敏感性影响，实际疾病负担可能更高[3]。
- 1Simons EA et al. Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability-Adjusted Life Years (DALYs). Risk Anal. 2016 Jul. PMID: 25115193. doi: 10.1111/risa.12263.PubMed: https://pubmed.ncbi.nlm.nih.gov/25115193/
- 2Moss WJ et al. Measles. Lancet. 2017 Dec 2. PMID: 28673424. doi: 10.1016/S0140-6736(17)31463-0.PubMed: https://pubmed.ncbi.nlm.nih.gov/28673424/
- 3World Health Organization. Rubella [Internet]. cited 3 Sept 2026.Available from: https://www.who.int/news-room/fact-sheets/detail/rubella
- P35.0
- KA63.0
数据覆盖
报告国家和地区
各报告国家的趋势
月度变化趋势
研究雷达
近期相关研究
Assessment of Commercial Lateral Flow Immunoassays for Rubella IgM Detection in Serum Samples
International Journal of Infectious Diseases
Rubella infection in pregnancy and congenital rubella in United Kingdom, 2003 to 2016
Eurosurveillance
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy
Vaccine
文献链接仅用于发现研究，不会改变或验证上方的监测序列。
数据获取
本页面数据索引，含来源链接和更新信息。
官方数据来源机构、频率与说明15
Australia NINDSS
Australia
Australian national notifiable diseases surveillance dashboard.
Australia NINDSS — Australian Capital Territory
Australian Capital Territory, Australia
Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.
Australia NINDSS — New South Wales
New South Wales, Australia
Australian NINDSS monthly state/territory notifications for New South Wales, kept separate from the Australia national aggregate.
Australia NINDSS — Northern Territory
Northern Territory, Australia
Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Queensland
Queensland, Australia
Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.
Australia NINDSS — South Australia
South Australia, Australia
Australian NINDSS monthly state/territory notifications for South Australia, kept separate from the Australia national aggregate.
Australia NINDSS — Tasmania
Tasmania, Australia
Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.
Australia NINDSS — Victoria
Victoria, Australia
Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.
Australia NINDSS — Western Australia
Western Australia, Australia
Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.
Brazil DATASUS SINAN
Brazil
Brazil Ministry of Health DATASUS/SINAN public DBC microdata aggregated to national monthly notification counts.
Canada PHAC CNDSS Annual
Canada
Canada is the national jurisdiction; subdivision feeds are registered separately.
Hong Kong, China CHP Notifiable Diseases
Hong Kong, China
Hong Kong, China CHP annual notifiable infectious disease CSVs normalized to national monthly totals
日本 NIID/JIHS 周报
Japan
日本 NIID/JIHS 周度传染病监测数据。
Korea KDCA EID
South Korea
Korea KDCA notifiable infectious disease OpenAPI or portal/KOSIS downloads aggregated to national monthly notification counts.
Taiwan, China CDC NIDSS
Taiwan, China
Taiwan, China monthly notifiable infectious disease open-data CSV feed.