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Inflammatory biomarkers of asymptomatic and symptomatic tuberculosis

Nature Communications·

Denis Awany, Dominique T. Ariefdien, Simon C. Mendelsohn, Virginie Rozot, Humphrey Mulenga, Sarah Nyangu, Michele Tameris, Tumelo Moloantoa, Austin Katona, Fernanda Maruri, Firdows Noor, Ravindre Panchia, Khuthadzo Hlongwane, Kim Stanley, Yuri F. van der Heijden, Katie Hadley, Andrew- Fiore Gartland, Craig Innes, William Brumskine, Keertan Dheda, Shameem Jaumdally, Tahlia Perumal, Neil Martinson, Al Leslie, Bernard Fourie, Andriëtte Hiemstra, Stephanus T. Malherbe, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Novel N. Chegou, Timothy R. Sterling, Mark Hatherill, Thomas J. Scriba, Pattamukkil Abraham, Thakiera Allie, Cynthia Baard, Zainab Baig, John Belisle, Nicole Bilek, Gerard Cangelosi, Ace Carstens, Kevyna Chetty, Yolundi Cloete, Marwou de Kock, Gareta Dickman, Charity Dire, Karen Dobos, Stephany Norah Duda, Mzwandile Erasmus, Marina Cruvinel Figueiredo, Marika Flinn, Travis Harris, Ryan Johnson, Farina Karim, Masooda Kaskar, Nobulumko Khomba, Thandeka Khoza, Léanie Kleynhans, Tahira Kootbodien, Andrea Kotze, Belinda A. Kriel, Ané Kruger, Lorraine Lichakane, Ilze Louw, Angelique Luabeya, Candice MacDonald, Lindiwe Madziwa, Lebohang Makhethe, Sandisiwe Mangali, Linda Mbuthini, Carolina Mehaffy, Thabang Moloja, Angelique Mouton, Evans Muchiri, Mbusiseni Ngema, Hlengiwe Nkambule, Onke Nombida, Alaina Olson, Fajwa Opperman, Gregory Ording-Jespersen, Kennedy Otwombe, Will Ramsay, Tracy Richardson, Carmen Segelaar, Jane Shaw, Kimberly Shelton, Justin Shenje, Theresa Smit, Bronwyn Smith, Candice Snyders, Marcia Steyn, Sara Suliman, Floris Swanepoel, Lorraine Thobakgale, Susanne Tonsing, Nicolette Tredoux, Megan Turner, Petrus Tyambetyuv, Habibullah Valley, Lyle van de Berg, Gian van der Spuy, Ilana R. van Rensburg, Johanna E. van Rooyen, Hilary Vansell Riley, Ashley Veldsman, Lindsay Wilson, Rachel C. Wood, Lesley Workman, Heather Zar, Charmaine Abrahams, Hadn Africa, Petri Ahlers, Laudicia Tshenolo Bontsi, Obakeng Peter Booi, Natasja Botes, Mari Cathrin Botha, Samentra Braaf, Sivuyile Buhlungu, Alida Carstens, Nompumelelo Cetywayo, Kgomotso Violet Chauke, Tilagavathy Chinappa, Eva Chung, Michelle Chung, Alessandro Companie, Cara-Mia Corris, Mooketsi Theophillius Cwaile, Thobelani Cwele, Ilse Davids, Isabella Johanna Davies, Emilia De Klerk, Bongani Diamond, Celaphiwe Dlamini, Margareth Erasmus, Elizabeth Filander, Hennie Geldenhuys, Dhineshree Govender, Yolande Gregg, Goodness Khanyisile Gumede, Nonhlanhla Zanele Elsie Gwamanda, Roxane Herling, Andriette Hiemstra, Senzo Ralph Hlathi, Blanchard Mbay Iyemosolo, Zandile Patrica Jali, Ruwiyda Jansen, James Michael Jeleni, Fazlin Kafaar, Christian Mabika Kasongo, Sebaetseng Jeanette Kekana, Xoliswa Kelepu, Justine Khoury, Lucky Sipho Khoza, Gloria Keitumetse Kolobe, Belinda Kriel, Lerato Julia Lekagane, Sheiley Christina Lekotloane, Ilze Jeanette Louw, Andre Loxton, Sarah Teboso Lusale, Elizna Maasdorp, Perfect Tiisetso Maatjie, Kamogelo Fortunate Mabena, Simbarashe Mabwe, Lauren Mactavie, Johanna Thapelo Madikwe, Octavia Mahkosazana Madikwev, Rapontwana Letlhogonolo Maebana, Nomsitho Magawu, Malobisa Sylvester Magwasha, Bhavna Maharaj, Lebohgang Makhete, Vutlhari-I-Vunhenha Fairlord Manzini, Nonhle Bridgette Maphanga, Jabulisiwe Lethabo Maphanga, Isholedi Samuel Maroele, Omphile Petunia Masibi, July Rocky Mathabanzini, Tendamudzimu Ivan Mathode, Ellen Ditaba Matsane, Lungile Mbata, Siyabonga Mbatha, Nyasha Karen Mhandire, Thembisiwe Miga, Nosisa Charity Thandeka Mkhize, Caroline Mkhokho, Neo Hilda Mkwalase, Nondzakazi Mnqonywa, Brenda Matshidiso Modisaotsile, Patricia Pakiso Mokgetsengoane, Selemeng Matseliso Carol Mokone, Kegomoditswe Magdeline Molatlhegi, Thuso Andrew Molefe, Motlatsi Evelyn Molotsi, Tebogo Edwin Montwedi, Boikanyo Dinah Monyemangene, Hellen Mokopi Mooketsi, Atika Moosa, Razia Hassan Moosa, Miriam Moses, Tshplpfelo Mapula Mosito, Ireen Lesebang Mosweu, Banyana Olga Motlagomang, Funeka Nomvula Mthembu, Liesel Muller, Nambitha Nqakala, Ntombozuko Gloria Ntanjana, Sphelele Simo Nzimande, Christel Petersen, Themba Phakathi, Mapule Ozma Phatshwane, Patiswa Plaatjie, Victor Kgothatso Rameetse, Frances Ratangee, Susan Rossouw, Alicia Sato, Kelebogile Magdeline Segaetsho, Ni Ni Sein, Melissa Neo Senne, Sifiso Cornelius Shezi, Thandiwe Yvonne Shezi, Zibuyile Phindile Penlee Sing, Zona Sithetho, Bongiwe Stofile, Sonia Stryers, Liticia Swanepoel, Mando Mmakhora Thaba, Lethabo Collen Theko, Dimakatso Sylvia Tsagae, Petrus Tyambetyu, Elma Van Rooyen, Helen Veldtsman, Mbali Ignatia Zulu

DOI
10.1038/s41467-026-75909-6
PMID
42649201
PMCID
OpenAlex
W4415678783
研究类型
Journal article
出版商
Springer Science and Business Media LLC
文章类型
journal-article
完整性状态
current

为何这项研究现在值得关注

研究结果提示,为有症状结核病分诊开发的生物标志物不应在未经进一步优化的情况下直接用于基于社区的无症状筛查。

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结构化证据摘要

研究问题

该研究探讨了通过社区筛查与医疗机构分诊发现的无症状与有症状结核病患者的血液转录组和蛋白质组特征是否存在差异。

研究设计

研究比较了南非社区筛查队列与医疗机构分诊队列的血液转录组和蛋白质组特征。

人群与场景

研究对象来自南非的社区筛查队列和医疗机构分诊环境。

主要发现

无症状结核病与有症状结核病具有共同的血液分子特征,包括先天免疫、干扰素和炎症通路上调以及淋巴细胞通路下调。无症状病例中存在两个不同亚群,其细菌负荷、干扰素-γ反应、体重指数和影像学表现存在差异。研究发现了一种新的无症状结核病血液转录组特征,但转录组和蛋白质组标志物对无症状结核病的诊断性能弱于有症状结核病。

公共卫生意义

研究结果提示,为有症状结核病分诊开发的生物标志物不应在未经进一步优化的情况下直接用于基于社区的无症状筛查。

重要局限

本摘要基于所提供的单篇文献摘要和元数据。关于队列选择、样本量、验证方法和结果推广性等研究局限性的完整解读需要查阅完整发表文章。

GIDS 解读

在索引同行评审传染病文献的监测平台中,可通过结核病疾病检索、南非国家筛选或诊断学与卫生政策主题筛选发现本文。

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相关 GIDS 监测

文献背景不会验证、解释或改变监测信号;精确关系与背景关系会分开展示。

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证据关系

本文与疾病、地区、主题及研究设计之间有 8 条可审计分类关系。

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