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同行评议开放获取流行性感冒

Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study

Clinical Infectious Diseases·

Nathaniel M Lewis, Elizabeth J Harker, Lauren B Grant, Yuwei Zhu, Carlos G Grijalva, James D Chappell, Jillian P Rhoads, Adrienne Baughman, Jonathan D Casey, Paul W Blair, Ian D Jones, Cassandra A Johnson, Adam S Lauring, Manju Gaglani, Shekhar Ghamande, Cristie Columbus, Jay S Steingrub, Nathan I Shapiro, Abhijit Duggal, Laurence W Busse, Jamie Felzer, Matthew E Prekker, Ithan D Peltan, Samuel M Brown, David N Hager, Michelle N Gong, Amira Mohamed, Matthew C Exline, Akram Khan, Catherine L Hough, Jennifer G Wilson, Jarrod Mosier, Nida Qadir, Steven Y Chang, Adit A Ginde, Amanda Martinez, Nicholas M Mohr, Christopher Mallow, Estelle S Harris, Nicholas J Johnson, Vasisht Srinivasan, Kevin W Gibbs, Jennie H Kwon, Ivana A Vaughn, Mayur Ramesh, Basmah Safdar, Anirudh Goyal, Lauren E DeLamielleure, Jennifer DeCuir, Diya Surie, Fatimah S Dawood, Mark W Tenforde, Timothy M Uyeki, Shikha Garg, Sascha Ellington, Wesley H Self, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande Nicole Calhoun, Kempapura Murthy, Joselyn Cravens, Judy Herrick, Amanda McKillop, Eric Hoffman, Ashley Graves, Martha Zayed, Michael Smith, Manjusha Gaglani, Cristie Columbus, Ashley Bychkowski, Symone Dunkley, Tammy Fisher, Therissa Grefsrud, Mariana Hurutado-Rodriguez, Gabriela Perez, Laurence Busse, Caitlin ten Lohuis, Jamie Felzer, Matthew Prekker, Audrey Hendrickson, Anne Frosch, Leyla Taghizadeh, Kowsar Hurreh, Mary O'Rourke, Laurynn Giles, Ivana A Vaughn, Mayur Ramesh, Lois E Lamerato, Khaled Almawri, Ishraaq Atkins, Jaleesa Clark, Jean Ashley Lava, Catherine McKeon, Zina Pinderi, Melissa Resk, Sindhuja Koneru, Rachna Jayaprakash, Shruti Tirumala, Katrina Williams, Ithan Peltan, Jenna Lumpkin, Shandi Poulson, Joslyn Bassett, Vineela Thumma, David N Hager, Harith Ali, Richard, Safa Saeed, Nicholas Mohr, Anne Zepeski, Paul Nassar, Jacob Hampton, Cathy Fairfield, Heath Gibbs, Courtney Feitsam, Ike Appleton, Michelle Ng Gong, Amira Mohamed, Luke Andrea, Matthew Exline, Sarah Karow, Gabrielle Swoope, Madison So, Manisha Pathak, David Smith, Reece Wilson, Zachery Lewald, Connor Snyder, Maryiam Khan, Brooke Lee, Amanie Rasul, Akram Khan, Adrian Hernandez-Frausto, Edvinas Pocius, Emily Tribbett, Genesis Briceno, Jose Pena, Sarah Pellicer, Raju Reddy, Gopal Allada, Jennifer Wilson, Alexandra June Gordon, Cynthia Perez, Lilian Lau, Samantha Ferguson, Vanessa Pitre, Grace Tam, Leonard Basobas, Jarrod Mosier, Karen Lutrick, Cameron Hypes, Beth Salvagio Campbell, Adit Ginde, Amanda Martinez, Aimee Steinwand, Amy Sullivan, Cori Withers, Jacob Rademacher, Rachel Obradovich, Chris Mallow, Carolina Rivas, Nicholas Johnson, Joshua Acidera, Katherine Elkort, Amol Gajendragadkar, Maile McKeown, Wesley H Self, H Keipp Talbot, Carlos Grijalva, Paul W Blair, Ian D Jones, Natasha Halasa, James D Chappell, Kelsey N Womack, Jillian Rhoads, Colleen Ratcliff, Adrienne Baughman, Jakea Johnson, Sydney Swan, Cassandra Johnson, Yuwei Zhu, Todd W Rice, Jonathan D Casey, Yuwei Zhu, Laura L Short, Lauren J Ezzell, Margaret E Whitsett, Rendie E McHenry, Samarian J Hargrave, Jennifer L Luther, Claudia Guevara Pulido, Bryan P M Peterson, Shanice L Cummings, Emma Claire Gauthier, Anna C Jackson, Neekar S Rashid, Marcia Blair, Caroline Rice, Jennie Kwon, Bijal Parikh, David McDonald, Carleigh Samuels, Lucy Vogt, Caroline O'Neil, Alyssa Valencia, Francesca Yerbic, Olivia Arter, Kim Vu, Basmah Safdar, Anirudh Goyal, Lauren DeLamielleure, Michael Kosover

DOI
10.1093/cid/ciae584
PMID
39607747
PMCID
PMC13016773
OpenAlex
W4404814594
研究类型
Journal article
出版商
Oxford University Press (OUP)
文章类型
journal-article
完整性状态
current

为何这项研究现在值得关注

研究结果支持现行临床指南中关于流感住院患者应尽早启动抗病毒治疗的建议。早期奥司他韦治疗与住院成人严重并发症和死亡的显著降低相关。

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结构化证据摘要

研究问题

该研究探讨了在住院当日启动奥司他韦治疗是否能降低实验室确诊流感住院成人患者的疾病严重程度和不良结局。

研究设计

这是一项多中心前瞻性观察研究,通过美国哨点监测网络在24家医院开展,时间为2022年10月至2023年7月。分析采用多变量回归模型比较入院当日启动奥司他韦患者与延迟治疗或未治疗患者的结局,并校正了基线严重程度、人口学特征、研究点和疫苗接种状态。

人群与场景

研究纳入了美国24家医院的840名实验室确诊流感的18岁及以上住院成人。其中415名患者(49%)在入院当日接受奥司他韦治疗,425名(51%)延迟接受或未接受治疗。

主要发现

与延迟治疗或未治疗患者相比,入院当日接受奥司他韦的患者肺部疾病峰值严重程度更低(校正OR 0.60,95% CI 0.49-0.72),ICU入住几率降低(校正OR 0.24,95% CI 0.13-0.47),急性肾脏替代治疗或血管加压药使用几率降低(校正OR 0.40,95% CI 0.22-0.67),院内死亡率降低(校正OR 0.36,95% CI 0.18-0.72)。

公共卫生意义

研究结果支持现行临床指南中关于流感住院患者应尽早启动抗病毒治疗的建议。早期奥司他韦治疗与住院成人严重并发症和死亡的显著降低相关。

重要局限

作为观察性研究,尽管进行了统计学校正,未测量的混杂因素仍可能影响治疗时机与结局之间的关联。本总结仅基于所提供的单篇文章摘要和元数据;决策级别的局限性解读、潜在偏倚和推广性评估需查阅原始论文。

GIDS 解读

这篇同行评审期刊文章被归类于美国流感监测和治疗主题。它提供了2022-2023年流感季节住院患者抗病毒药物有效性的证据,但不代表监测信号或趋势分析。

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相关 GIDS 监测

文献背景不会验证、解释或改变监测信号;精确关系与背景关系会分开展示。

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证据关系

本文与疾病、地区、主题及研究设计之间有 11 条可审计分类关系。

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