Preventing the spread of multidrug-resistant tuberculosis and protecting contacts of infectious cases
Clinical Microbiology and Infection·
- DOI
- 10.1016/j.cmi.2016.08.024
- PMID
- 27592087
- PMCID
- PMC11849722
- OpenAlex
- W2509042206
- Study type
- Systematic review
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Addressing resistant tuberculosis strains represents a critical global health objective due to the severe financial burdens, adverse drug effects, and suboptimal recovery rates associated with conventional management approaches.
Structured evidence summary
Research question
The authors sought to assess available evidence regarding interventions that could decrease the transmission and clinical advancement of multidrug-resistant and extensively drug-resistant tuberculosis.
Study design
The manuscript presents a systematic literature review synthesizing existing research on tuberculosis control strategies.
Population and setting
The analysis considers healthcare environments such as hospitals and clinics, broader community clusters, and individuals identified as close contacts of infectious patients across regions with elevated disease prevalence.
Main findings
Accelerated diagnostic procedures combined with prompt therapeutic initiation effectively reduce patient infectivity. Expanded deployment of molecular assays improves case identification in resource-constrained areas, while targeted community screening and contact prophylaxis demonstrate potential benefits primarily backed by observational data.
Public-health relevance
Addressing resistant tuberculosis strains represents a critical global health objective due to the severe financial burdens, adverse drug effects, and suboptimal recovery rates associated with conventional management approaches.
Important limitations
Current recommendations for prophylactic interventions among exposed individuals rely exclusively on observational cohort data, highlighting an urgent requirement for controlled experimental trials to validate efficacy and inform regulatory frameworks.
GIDS interpretation
This peer-reviewed synthesis is indexed under topics covering pathogen transmission, drug resistance, clinical management, and health administration. It functions as a consolidated reference for existing intervention methodologies rather than a primary epidemiological report.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.