Efficacy of bedaquiline in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-021-06666-8
- PMID
- 34535090
- PMCID
- PMC8447831
- OpenAlex
- W3161434247
- Study type
- Systematic review
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Drug-resistant tuberculosis remains a major public health concern worldwide. The findings suggest bedaquiline has the potential to improve outcomes among drug-resistant tuberculosis cases.
Structured evidence summary
Research question
The review assessed the efficacy of bedaquiline on treatment outcomes in patients with drug-resistant tuberculosis.
Study design
This was a systematic review and meta-analysis of eight studies (two randomized controlled trials and six cohort studies) involving 21,836 subjects. Studies were included if participants received bedaquiline versus no bedaquiline. Quality was assessed using the Jadad scale for trials and the Newcastle-Ottawa scale for cohort studies.
Population and setting
The review included patients with drug-resistant tuberculosis, specifically those with multidrug-resistant tuberculosis eligible for WHO-recommended all-oral regimens.
Main findings
Bedaquiline treatment was associated with higher culture conversion rates (RR 1.272, 95% CI 1.165-1.389, P<0.001) and lower mortality (RR 0.734, 95% CI 0.618-0.872, P<0.001) compared with control. Treatment success was higher in the bedaquiline group (RR 1.197, 95% CI 1.110-1.290, P<0.001).
Public-health relevance
Drug-resistant tuberculosis remains a major public health concern worldwide. The findings suggest bedaquiline has the potential to improve outcomes among drug-resistant tuberculosis cases.
Important limitations
This summary is limited to the supplied single-article abstract and metadata. Full interpretation of heterogeneity, study quality scores, individual study characteristics, and clinical applicability requires review of the complete published article.
GIDS interpretation
This peer-reviewed systematic review was classified with tuberculosis, multidrug-resistant tuberculosis, treatment, and antimicrobial resistance topics. The study synthesizes evidence on bedaquiline efficacy for editorial and research discoverability purposes.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 6 auditable classifier relationships to diseases, places, topics, and study design.