Generational selection, transcriptomics and functional characterization reveal the impact of environmental pollutants on the evolution of insecticide resistance in malaria vectors.
Insect biochemistry and molecular biology·
- DOI
- 10.1016/j.ibmb.2026.104661
- PMID
- 42603676
- PMCID
- —
- OpenAlex
- W7135070940
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Relevant to malaria control because it addresses insecticide resistance in malaria vectors and suggests environmental pollutants may be part of the resistance context.
Structured evidence summary
Research question
To examine whether exposure to environmental PAHs affects the evolution of insecticide resistance in malaria-vector Anopheles populations.
Study design
Journal article reporting a multi-generational selection experiment with PAHs, WHO bioassays, RNA sequencing, and heterologous gene-expression testing.
Population and setting
Field insecticide-resistant An. coluzzii from Auyo and a laboratory-susceptible Ngousso colony were studied under experimental selection with naphthalene, fluorene, or both.
Main findings
After ten generations, PAH-selected field lines had lower pyrethroid and DDT resistance than non-selected controls, while the laboratory line showed higher DDT resistance and a later increase in permethrin resistance. Several detoxification and Ahr-pathway genes were overexpressed, and CYP6M4 metabolized multiple pyrethroids and the two PAHs in heterologous expression.
Public-health relevance
Relevant to malaria control because it addresses insecticide resistance in malaria vectors and suggests environmental pollutants may be part of the resistance context.
Important limitations
This summary is limited to the supplied single-article abstract and metadata; the original paper is needed for full methods, context, and decision-grade interpretation.
GIDS interpretation
The article is discoverable as evidence on malaria-vector resistance, environmental pollutants, and transcriptomic/functional mechanisms, but the abstract alone does not support a live surveillance interpretation.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 4 auditable classifier relationships to diseases, places, topics, and study design.