Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment
International Journal of Infectious Diseases·
- DOI
- 10.1016/j.ijid.2026.109078
- PMID
- 42679922
- PMCID
- —
- OpenAlex
- W7204911829
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The co-occurrence of resistance-associated markers and treatment failure in one patient is presented as justification for ongoing genomic surveillance of antimalarial resistance.
Structured evidence summary
Research question
The article describes co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection after standard artemether-lumefantrine treatment and motivates genomic surveillance of antimalarial resistance and study of host factors.
Study design
The bibliographic metadata classifies the work as a peer-reviewed journal article; the abstract phrasing ("We report") is consistent with a single-patient case report.
Population and setting
A single patient with metabolic comorbidities who experienced recurrent P. falciparum infection following standard artemether-lumefantrine therapy.
Main findings
Recurrent P. falciparum infection was observed after standard artemether-lumefantrine treatment, with mutant parasites carrying both pfkelch13 and pfmdr1 variants. The abstract also flags host factors as potentially affecting antimalarial drug exposure.
Public-health relevance
The co-occurrence of resistance-associated markers and treatment failure in one patient is presented as justification for ongoing genomic surveillance of antimalarial resistance.
Important limitations
The abstract does not state explicit limitations. This summary is limited to the supplied single-article abstract and metadata and requires the original paper for decision-grade interpretation.
GIDS interpretation
The article fits the GIDS topics of Genomic epidemiology, Surveillance, and Treatment for malaria. It indicates that the authors view resistance-marker monitoring as a relevant surveillance activity, but no connection to a live surveillance signal is established from the supplied evidence.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.