Influenza A-Associated Pulmonary Aspergillosis in Critically Ill Patients in the Post-COVID-19 Era: A Multicenter Cohort Study from China
International Journal of Infectious Diseases·
- DOI
- 10.1016/j.ijid.2026.109089
- PMID
- 42668058
- PMCID
- —
- OpenAlex
- W7204645151
- Study type
- Cohort study
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The authors highlight a high prevalence and rapid onset of influenza-associated pulmonary aspergillosis in critically ill patients and call for protocolized screening and timely diagnostics.
Structured evidence summary
Research question
The study examined how often invasive pulmonary aspergillosis occurs in adults with severe Influenza A pneumonia, what factors raise the risk, and how it affects survival in a post-COVID-19 Chinese setting.
Study design
A multicenter retrospective cohort study conducted across 21 intensive care units between November 2024 and February 2025, using the 2024 FUNDICU criteria for aspergillosis classification.
Population and setting
Critically ill adults with acute respiratory failure from confirmed severe Influenza A pneumonia, treated in 21 Chinese ICUs during a single influenza season.
Main findings
Among 542 patients, 33.0% met criteria for invasive pulmonary aspergillosis, with a median of two days from influenza onset to diagnosis. Renal replacement therapy, diabetes, bacterial co-infection, and systemic glucocorticoid use before or during the ICU stay were independently associated with aspergillosis. Sixty-day all-cause mortality was higher in patients with aspergillosis than in those without.
Public-health relevance
The authors highlight a high prevalence and rapid onset of influenza-associated pulmonary aspergillosis in critically ill patients and call for protocolized screening and timely diagnostics.
Important limitations
No explicit limitations are reported in the abstract. The summary is therefore restricted to the supplied single-article abstract and metadata, and decision-grade interpretation would require review of the full paper.
GIDS interpretation
This article is discoverable through links to influenza and COVID-19 as topic areas and to China as the geographic setting, providing contextual metadata rather than any linkage to a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.