An MDR Salmonella Enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China
Journal of Infection·
- DOI
- 10.1016/j.jinf.2025.106421
- PMID
- 39855357
- PMCID
- —
- OpenAlex
- W4406731009
- Study type
- Genomic study
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The supplied abstract identifies multidrug-resistant Salmonella Enteritidis clades associated with reported gastroenteritis outbreaks and invasive disease in China. It describes implications for monitoring bacterial population changes and for further genomic epidemiological investigation, but does not establish causal effects or quantify risk beyond the studied isolates.
Structured evidence summary
Research question
The study examined the genomic structure, antimicrobial resistance, virulence-associated features, and evolutionary history of a multidrug-resistant Salmonella Enteritidis sublineage linked in the supplied abstract to gastroenteritis outbreaks and invasive disease in China.
Study design
This was a genomic study using whole-genome sequencing, antimicrobial-resistance testing, phylogenomic analysis, and molecular characterization of resistance genes, virulence factors, mobile genetic elements, and pan-genomes. The analysis covered isolates collected over 28 years and compared Chinese isolates with a global context.
Population and setting
The study analyzed 729 Chinese Salmonella Enteritidis isolates collected from gastroenteritis outbreaks, sporadic gastrointestinal infections, and invasive nontyphoidal Salmonella infections between 1994 and 2021. The setting was China, with isolates examined across multiple regions and in relation to a global phylogenomic framework.
Main findings
The isolates showed substantial multidrug resistance, including frequent nalidixic-acid resistance, and the abstract reports an increase in multidrug resistance among invasive-disease isolates during the preceding decade. Most isolates belonged to global lineage L1, with Chinese isolates concentrated in sublineages L1.2 and L1.3 that formed two principal Chinese clades; these clades carried many resistance and virulence determinants, including plasmid-associated features.
Public-health relevance
The supplied abstract identifies multidrug-resistant Salmonella Enteritidis clades associated with reported gastroenteritis outbreaks and invasive disease in China. It describes implications for monitoring bacterial population changes and for further genomic epidemiological investigation, but does not establish causal effects or quantify risk beyond the studied isolates.
Important limitations
The supplied evidence is limited to a single article's abstract and bibliographic metadata; the original paper is required for decision-grade assessment of sampling, representativeness, statistical analyses, definitions, and study limitations. The abstract describes genomic and epidemiological associations but does not provide sufficient detail to establish causality or generalize findings beyond the analyzed isolates and setting.
GIDS interpretation
The article is discoverable under gastroenteritis, China, antimicrobial resistance, genomic epidemiology, outbreak investigation, and surveillance. Within this evidence set, it provides context about a reported Chinese Salmonella Enteritidis genomic pattern; it does not confirm or characterize a current surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.