A rare case of breakthrough tick-borne encephalitis in early adolescence after vaccination with four doses of TBE vaccine.
New microbes and new infections·
- DOI
- 10.1016/j.nmni.2026.101720
- PMID
- 41732518
- PMCID
- PMC12924906
- OpenAlex
- W7127536217
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The documentation emphasizes the continued possibility of serious neurological illness in fully immunized populations. It also suggests that medical professionals should maintain awareness of infectious triggers when evaluating acute inflammatory symptoms.
Structured evidence summary
Research question
How can clinicians characterize the clinical trajectory and laboratory markers associated with a rare post-vaccination neurological complication?
Study design
This investigation utilizes a descriptive case report format to document a single patient encounter.
Population and setting
The subject is a previously healthy adolescent who had received four prior vaccinations against the targeted pathogen.
Main findings
The individual developed severe encephalitis requiring extended hospitalization despite complete immunization history. Laboratory analysis indicated a postponed IgM reaction but demonstrated early IgG production targeting the NS1 protein within cerebrospinal fluid. Longitudinal imaging confirmed enduring neurological alterations, while the precise drivers of the severe progression were not determined.
Public-health relevance
The documentation emphasizes the continued possibility of serious neurological illness in fully immunized populations. It also suggests that medical professionals should maintain awareness of infectious triggers when evaluating acute inflammatory symptoms.
Important limitations
The singular focus on one patient prevents generalization to wider demographic groups or definitive mechanistic conclusions. Authors explicitly acknowledge that the factors contributing to the severe clinical course remain unknown.
GIDS interpretation
This record offers background context on atypical immunological profiles and diagnostic methodologies following prophylactic administration. It functions as a reference resource for understanding complex clinical presentations without implying active monitoring activity.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.