The use of pseudotypes to study viruses, virus sero-epidemiology and vaccination
Vaccine·
- DOI
- 10.1016/j.vaccine.2015.04.071
- PMID
- 25936665
- PMCID
- PMC7127415
- OpenAlex
- W2003947861
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The article identifies pseudotype technology as relevant to research on pathogens described as important to human and animal health, particularly where access to high-containment facilities is limited. The abstract supports a research and laboratory-capacity relevance, but does not provide evidence of population-level health effects.
Structured evidence summary
Research question
The article describes how pseudotyped viruses can support research on virus biology, serology, serosurveillance, vaccine immunogenicity, and assay development for important human and animal pathogens.
Study design
This is a peer-reviewed journal article reporting on a pseudotype-focused scientific conference and summarizing the technologies and topics discussed there. It is not presented as a primary epidemiological or experimental outcome study.
Population and setting
The article addresses laboratory research involving human and animal viruses, including influenza, rabies or lyssaviruses, HIV, Marburg virus, and Ebola virus. The supplied abstract does not define a participant population or a geographic study setting.
Main findings
The article reports that non-pathogenic, replication-defective pseudotypes are used to study aspects of virus biology in lower-containment laboratories than those required for some pathogenic viruses. The conference covered applications in serology, serosurveillance, vaccine immunogenicity assessment, multiplexing, and assay-kit development.
Public-health relevance
The article identifies pseudotype technology as relevant to research on pathogens described as important to human and animal health, particularly where access to high-containment facilities is limited. The abstract supports a research and laboratory-capacity relevance, but does not provide evidence of population-level health effects.
Important limitations
The supplied material is a conference-focused journal article based on the abstract and bibliographic metadata, rather than a primary study with defined participants, comparative analyses, or quantitative outcomes. Decision-grade interpretation requires review of the original paper and the underlying conference evidence.
GIDS interpretation
This article is discoverable as contextual literature on pseudotype methods, serology, serosurveillance, and vaccination research involving several viral pathogens. It does not provide evidence that any current surveillance signal is confirmed or characterized.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 13 auditable classifier relationships to diseases, places, topics, and study design.