Humoral and cellular immune responses in sheep following administration of different doses of an inactivated phase I vaccine against Coxiella burnetii
Vaccine·
- DOI
- 10.1016/j.vaccine.2023.06.061
- PMID
- 37357077
- PMCID
- —
- OpenAlex
- W4381929969
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
This article is relevant to vaccination strategy for sheep in the context of coxiellosis/Q fever prevention. It adds context on dose and booster effects for a licensed inactivated phase I vaccine used in ovine settings.
Structured evidence summary
Research question
The study examined whether sheep given 1 mL versus 2 mL of an inactivated phase I Coxiella burnetii vaccine show different humoral and cellular immune responses, and whether a later booster changes those responses.
Study design
Randomized comparison in 18 gimmers assigned to two vaccine-dose groups and one saline control group. The animals received two primary injections three weeks apart, followed by a booster about nine months later, with immune markers and local/systemic reactions measured over time.
Population and setting
Eighteen gimmers from a flock described as unsuspected for C. burnetii were studied. The work was done in sheep and focused on an ovine vaccination context.
Main findings
After vaccination, sheep had a brief temperature increase and only minor swelling at the injection site. The abstract reports an early IgM/IgG phase II response, later predominance of IgG phase I, and a stronger IgG phase I and IFN-gamma response after the booster; neutralizing activity was described as broader with 1 mL than with 2 mL. The authors state that dose differences were small, that 1 mL appears adequate, and that a booster was apparently needed to strengthen cell-mediated immunity.
Public-health relevance
This article is relevant to vaccination strategy for sheep in the context of coxiellosis/Q fever prevention. It adds context on dose and booster effects for a licensed inactivated phase I vaccine used in ovine settings.
Important limitations
The abstract describes a small study in 18 animals from a single flock, so broader generalization is limited. It reports immune and reactogenicity measures, not clinical protection or field effectiveness. This summary is limited to the supplied abstract and metadata; the original paper would be needed for decision-grade interpretation.
GIDS interpretation
The article is readily discoverable as a peer-reviewed Vaccine paper on Q fever vaccination in sheep and provides contextual evidence about dose-related immune responses. The supplied abstract does not support any live surveillance signal or population-level trend interpretation.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.