Transmission of drug-resistant tuberculosis in HIV-endemic settings
The Lancet Infectious Diseases·
- DOI
- 10.1016/s1473-3099(18)30537-1
- PMID
- 30554996
- PMCID
- PMC6474238
- OpenAlex
- W2904327006
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The work underscores the necessity of coordinated regional control measures to mitigate escalating antimicrobial resistance and reduce community-wide pathogen dissemination.
Structured evidence summary
Research question
How do virological and demographic factors shape the dissemination of multidrug-resistant tuberculosis in regions with substantial human immunodeficiency virus prevalence, and what investigative gaps require resolution?
Study design
The publication operates as a narrative review within a journal series, synthesizing existing literature to outline current knowledge and establish future investigative priorities.
Population and setting
Communities located in geographic areas experiencing concurrent high prevalence of human immunodeficiency virus and multidrug-resistant tuberculosis.
Main findings
Human immunodeficiency virus accelerates tuberculosis disease progression, which subsequently drives higher transmission rates of drug-resistant strains. The authors identify targeted diagnostic tools, optimized therapeutic regimens, strict environmental controls, and systematic contact tracing as essential control strategies. They emphasize that population-level genetic tracking studies are necessary to clarify ongoing transmission drivers.
Public-health relevance
The work underscores the necessity of coordinated regional control measures to mitigate escalating antimicrobial resistance and reduce community-wide pathogen dissemination.
Important limitations
The summary is limited to the supplied single-article abstract and metadata, requiring the original paper for decision-grade interpretation.
GIDS interpretation
This document serves as a conceptual reference for mapping literature trends regarding resistant pathogen spread in co-epidemic zones, offering contextual framing for topic classification rather than indicating active epidemiological monitoring.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.