Immune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine
npj Vaccines·
- DOI
- 10.1038/s41541-023-00630-0
- PMID
- 36899062
- PMCID
- PMC10005913
- OpenAlex
- W4323921279
- Study type
- Randomised controlled trial
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Establishing quantitative immunological benchmarks may assist regulatory agencies in evaluating vaccine performance during approval pathways.
Structured evidence summary
Research question
The investigation examines whether quantifiable antibody measurements can predict susceptibility to symptomatic SARS-CoV-2 infection following primary vaccination.
Study design
Researchers performed a case-cohort analysis utilizing data extracted from a multinational phase 3 randomized controlled trial.
Population and setting
The analytical cohort consisted of SARS-CoV-2 negative individuals enrolled in the trial across the United States, Chile, and Peru.
Main findings
Elevated anti-spike IgG concentrations and higher neutralizing antibody titers correlated with reduced infection risk. Estimated protection rates demonstrated substantial improvement as antibody levels surpassed low detection thresholds.
Public-health relevance
Establishing quantitative immunological benchmarks may assist regulatory agencies in evaluating vaccine performance during approval pathways.
Important limitations
The evaluation utilizes a sampled subset of trial participants rather than the complete cohort. Since explicit methodological constraints are not detailed in the provided materials, this summary relies exclusively on the supplied single-article abstract and metadata, requiring the original paper for decision-grade interpretation.
GIDS interpretation
This record supplies contextual reference material for literature tracking focused on immunological validation and vaccine policy frameworks.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.