Genomic epidemiology and evolutionary dynamics of Bordetella pertussis: A comparative study between China and Global Strains (2018–2024)
International Journal of Infectious Diseases·
- DOI
- 10.1016/j.ijid.2026.108397
- PMID
- 41579932
- PMCID
- —
- OpenAlex
- W7125495808
- Study type
- Genomic study
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The convergence of resistance, hypervirulence, and potential vaccine escape within a dominant lineage is framed by the authors as grounds to revisit antibiotic stewardship and pertussis vaccination strategies.
Structured evidence summary
Research question
The study set out to characterize the global origins, evolutionary trajectory, and adaptive features of the macrolide-resistant MT28-ptxP3 lineage of Bordetella pertussis implicated in a recent resurgence.
Study design
Integrative genomic epidemiology combining long-term surveillance from Shenzhen (2013–2024) with comparative genomic analysis of 632 B. pertussis isolates collected between 2018 and 2024, using MLVA and SNP-based phylogenetics.
Population and setting
Surveillance setting in Shenzhen, China, spanning 2013–2024, with comparative isolates from the United States, Japan, Austria, and Vietnam to contextualize the Chinese strains within a global sample.
Main findings
An MT28 lineage expanded from 6.5% in 2018 to 89.4% in 2024 within the Shenzhen sample. The 2024 resurgence was attributed to localized fixation of macrolide resistance within the globally dispersed MT28 lineage, with the lineage combining resistance, hypervirulence markers, and prn deficiency suggestive of vaccine escape.
Public-health relevance
The convergence of resistance, hypervirulence, and potential vaccine escape within a dominant lineage is framed by the authors as grounds to revisit antibiotic stewardship and pertussis vaccination strategies.
Important limitations
The supplied evidence does not enumerate explicit study limitations; this summary is restricted to the supplied single-article abstract and metadata and would require the original paper for decision-grade interpretation.
GIDS interpretation
The article is relevant to GIDS topics on pertussis genomic epidemiology, antimicrobial resistance, vaccination, and surveillance; however, no claim is made that live GIDS signals confirm the paper's findings.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 11 auditable classifier relationships to diseases, places, topics, and study design.