High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014–2016
Emerging Infectious Diseases·
- DOI
- 10.3201/eid2512.181836
- PMID
- 31742507
- PMCID
- PMC6874251
- OpenAlex
- W2982448875
- Study type
- Journal article
- Publisher
- Centers for Disease Control and Prevention (CDC)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
High prevalence of macrolide-resistant B. pertussis in China may affect treatment options for pertussis patients. The findings support consideration of sulfamethoxazole/trimethoprim as an alternative for infections caused by erythromycin-resistant strains.
Structured evidence summary
Research question
This study examined the genetic characteristics and antimicrobial resistance patterns of Bordetella pertussis isolates collected in mainland China between 2014 and 2016.
Study design
The study used multilocus variable-number tandem-repeat analysis (MLVA) to genotype 335 B. pertussis isolates from China, comparing them with strains from Western countries. Antimicrobial susceptibility testing was performed for erythromycin and sulfamethoxazole/trimethoprim.
Population and setting
Clinical isolates were collected from mainland China during 2014–2016, with geographic comparison between northern and southern regions.
Main findings
The predominant genotype was ptxA1/ptxC1/ptxP1/prn1/fim2-1/fim3A/tcfA2, more common in northern China and highly resistant to erythromycin. A minority of strains (36/335) carried ptxP3, were sensitive to erythromycin, and mainly harbored ptxA1 and prn2. All isolates showed low MICs for sulfamethoxazole/trimethoprim. MLVA typing of 150 isolates identified 13 types with 3 predominant patterns that differed from those circulating in Western countries.
Public-health relevance
High prevalence of macrolide-resistant B. pertussis in China may affect treatment options for pertussis patients. The findings support consideration of sulfamethoxazole/trimethoprim as an alternative for infections caused by erythromycin-resistant strains.
Important limitations
This summary is limited to the supplied single-article abstract and metadata. Full interpretation of study limitations, sampling methodology, representativeness of isolates, and clinical outcome correlations requires review of the complete published article.
GIDS interpretation
This article is discoverable through classifier links for pertussis, China, antimicrobial resistance, surveillance, and vaccination topics. These links reflect the study's content domain and facilitate retrieval in literature monitoring systems, but do not indicate association with a specific surveillance alert or outbreak investigation.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.