Effects of Influenza Vaccination in the United States During the 2018–2019 Influenza Season
Clinical Infectious Diseases·
- DOI
- 10.1093/cid/ciz1244
- PMID
- 31905401
- PMCID
- PMC7643742
- OpenAlex
- W2998914842
- Study type
- Mathematical modelling
- Publisher
- Oxford University Press (OUP)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
These quantitative assessments reinforce the operational importance of routine immunization campaigns in mitigating severe clinical burdens and sustaining healthcare system capacity during variable seasonal conditions.
Structured evidence summary
Research question
The investigation aimed to quantify the reduction in influenza-related health outcomes attributable to immunization efforts throughout a specific seasonal cycle in the United States.
Study design
Researchers applied a computational simulation framework combined with probabilistic sampling techniques to project prevented health events.
Population and setting
The analysis focused on the national demographic across the 2018–2019 winter period, incorporating stratified metrics for pediatric cohorts.
Main findings
Computational projections indicated that immunization efforts averted approximately 4.4 million infections, 2.3 million outpatient encounters, 58,000 acute care admissions, and 3,500 fatalities. Protective impact was particularly pronounced against the well-aligned viral subtype, while also demonstrating measurable utility despite partial antigenic divergence in another circulating strain.
Public-health relevance
These quantitative assessments reinforce the operational importance of routine immunization campaigns in mitigating severe clinical burdens and sustaining healthcare system capacity during variable seasonal conditions.
Important limitations
The abstract does not outline specific methodological constraints or data gaps. Consequently, this summary is limited to the supplied single-article abstract and metadata, and requires the original paper for decision-grade interpretation.
GIDS interpretation
This record serves as a historical reference point for evaluating past immunization performance within a defined geographic and temporal boundary. Its cataloging aids academic tracking of seasonal vaccine impact without suggesting alignment with ongoing monitoring networks.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.