Evidence of chikungunya virus reinfection in two patients with lupus during the 2024–2025 outbreak on Reunion Island
Open Forum Infectious Diseases·
- DOI
- 10.1093/ofid/ofag534
- PMID
- —
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Oxford University Press (OUP)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The observations suggest that assumptions of durable chikungunya immunity may not hold universally, which could inform risk communication and clinical management for vulnerable groups during outbreaks.
Structured evidence summary
Research question
The study examines whether chikungunya virus reinfection can occur in patients with systemic lupus erythematosus during the 2024–2025 Reunion Island outbreak, questioning the paradigm of prolonged post-infection immunity.
Study design
A descriptive report identifying one confirmed and one probable reinfection case among patients with systemic lupus erythematosus during a defined outbreak period.
Population and setting
Two patients with systemic lupus erythematosus who experienced chikungunya virus infection during the 2024–2025 outbreak on Reunion Island.
Main findings
One confirmed and one probable reinfection were identified in lupus patients, suggesting that reinfection may occur in specific populations and pointing to a more complex pathophysiology than prolonged sterilizing immunity.
Public-health relevance
The observations suggest that assumptions of durable chikungunya immunity may not hold universally, which could inform risk communication and clinical management for vulnerable groups during outbreaks.
Important limitations
The summary is limited to the supplied single-article abstract/metadata and requires the original paper for decision-grade interpretation; explicit limitations such as sample size, diagnostic criteria, or immunological workup are not stated in the abstract.
GIDS interpretation
Indexed under chikungunya and outbreak investigation; discoverability is supported by disease and topic classifier links, which may aid retrieval during outbreak-related literature surveillance.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 6 auditable classifier relationships to diseases, places, topics, and study design.