Molecular epidemiology and antimicrobial resistance of group a streptococcus recovered from patients in Beijing, China
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-020-05241-x
- PMID
- 32660436
- PMCID
- PMC7359455
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Publication version
This article has a linked preprint
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Open linked preprint →Why this research matters now
The findings document high macrolide resistance and common emm and superantigen profiles in the sampled Beijing hospital isolates, supporting the authors' stated need for long-term monitoring.
Structured evidence summary
Research question
The study investigated molecular epidemiological characteristics, antimicrobial resistance, emm types, macrolide-resistance genes, and superantigen gene profiles among GAS isolates from patients with scarlet fever at a children's hospital in Beijing.
Study design
This was a hospital-based descriptive laboratory study of pharyngeal swab samples collected from outpatients diagnosed with scarlet fever during 2016–2017, with antimicrobial susceptibility testing and PCR-based characterization.
Population and setting
The study included 297 GAS isolates collected from outpatients at Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Main findings
All isolates were susceptible to penicillin, ceftriaxone, and levofloxacin. Resistance to erythromycin and clindamycin was reported in 98.3% and 96.6%, respectively. emm12 and emm1 were the dominant types; ermB was detected in 97.64% of isolates, and the study reported an association between emm type and superantigen gene profile.
Public-health relevance
The findings document high macrolide resistance and common emm and superantigen profiles in the sampled Beijing hospital isolates, supporting the authors' stated need for long-term monitoring.
Important limitations
The summary is limited to the supplied single-article abstract and metadata. The samples came from outpatients at one children's hospital in Beijing during 2016–2017, and the abstract does not provide sampling-frame or representativeness details; the original paper is required for decision-grade interpretation.
GIDS interpretation
The article is indexed as relevant to scarlet fever, China, antimicrobial resistance, surveillance, and treatment. This classification provides publication context only and does not establish a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.