End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17
Eurosurveillance·
- DOI
- 10.2807/1560-7917.es.2017.22.44.17-00306
- PMID
- 29113630
- PMCID
- PMC5710133
- OpenAlex
- W2765711703
- Study type
- Case-control study
- Publisher
- European Centre for Disease Control and Prevention (ECDC)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
These results bolster the rationale for sustaining youth immunization initiatives while underscoring the continued necessity of developing robust protective strategies for elderly populations.
Structured evidence summary
Research question
What is the adjusted end-of-season immunization performance against laboratory-confirmed respiratory infections across distinct age cohorts in the United Kingdom during the 2016/17 period?
Study design
The investigation utilized a test-negative case-control methodology implemented within primary care environments to quantify protective outcomes.
Population and setting
The analysis encompassed primary care patients located in the United Kingdom, with stratified reporting for pediatric and adult demographics throughout the designated influenza season.
Main findings
Overall adjusted protection reached approximately forty percent against confirmed infections. Working-age adults demonstrated measurable benefit, whereas older seniors showed no statistically significant advantage. School-aged children who received the live attenuated formulation exhibited considerably higher protection rates.
Public-health relevance
These results bolster the rationale for sustaining youth immunization initiatives while underscoring the continued necessity of developing robust protective strategies for elderly populations.
Important limitations
The evaluation relies on a test-negative case-control framework restricted to primary care attendees, which may constrain applicability to wider community or hospital-based outcomes. Furthermore, this summary depends exclusively on the provided abstract and metadata, requiring the original manuscript for decision-grade interpretation.
GIDS interpretation
This publication supplies historical context concerning regional immunization performance and viral strain alignment for a specific influenza season. It operates as a reference point for assessing past programmatic evaluations rather than reflecting current epidemiological monitoring.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 15 auditable classifier relationships to diseases, places, topics, and study design.