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Geographic evidence hub

United Kingdom research

Published infectious-disease research classified with a high-confidence geographic relationship to United Kingdom.

Published evidence
35
Diseases
23
Countries
27
Topics
13

Evidence stream

Published literature

35

30 of 35 publications shown

Negotiating security and resilience: planning conundrums for avian influenza control in Great Britain’s poultry systems

Mathew Hennessey, Pablo Alarcon, Paniz Hosseini +2 more

Environmental Research: Food Systems

Type
Journal article
Scope
United Kingdom

Why it matters nowThe research highlights critical gaps in agricultural risk management that could facilitate pathogen persistence and impact broader food security frameworks.

Peer reviewedOpen accessAIDS
DOI 10.1177/10901981261479324 ↗

Do Digital Visual Aids Improve Skin Self-Examination Behaviours? A Systematic Review

Heba Abdalla, Johanna Joyce, Nurul Amanina Binte Hussain +1 more

Health Education & Behavior

Type
Systematic review
Scope
Australia, United Kingdom, United States

Why it matters nowSkin self-examination represents a secondary prevention approach for early skin cancer detection. Digital visual aids such as smartphone applications may support broader uptake and maintenance of these examination behaviors.

Heterogeneity of use, access, and retention of insecticide-treated nets: Implications for subnational tailoring to maximise malaria control

Andrew C Glover, Hannah Koenker, El Hadji Amadou Niang +2 more

eLife

Type
Journal article
Scope
Burkina Faso, United Kingdom, Ghana

Why it matters nowThe findings indicate that subnational variation in net use after access may be relevant when considering malaria-control deployment strategies. The abstract describes a framework for using routinely collected data to support subnational programme tailoring.

Effectiveness of Influenza Vaccines and Duration of Protection Against Hospitalisation During the 2024/25 Season in Northern Ireland, UK

Magda Bucholc, Siobhán Murphy, Mark G. O'Doherty +3 more

Influenza and Other Respiratory Viruses

Type
Journal article
Scope
United Kingdom, Ireland

Why it matters nowThe findings indicate that seasonal influenza vaccination provided meaningful protection against hospitalisation in 2024/25, with the largest benefit observed in children, supporting continued vaccination efforts in Northern Ireland.

ChAdOx1 nCoV-19 coronavirus vaccine: Long-term safety and immunological responses

Narges Ebrahimi, Philip de Whalley, Nasir Kanji +32 more

Vaccine

Type
Journal article
Scope
United Kingdom

Why it matters nowTracking extended safety outcomes in vaccinated populations aligns with established priorities for evaluating long-term product performance in preventive healthcare frameworks.

Effects of attenuated influenza virus administration to young children on pneumococcal density and acquisition in UK families: a randomised controlled trial

Jane Metz, George Qian, Begonia Morales-Aza +16 more

The Lancet Microbe

Type
Randomised controlled trial
Scope
United Kingdom

Why it matters nowThe findings suggest LAIV-induced increases in pneumococcal density in vaccinated toddlers may transiently raise pneumococcal acquisition risk among household members, which has implications for transmission modelling at individual and population scales.

The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study

Julia E Marshall, Noemie Lefrancq, Lewis C E Mason +5 more

The Lancet Infectious Diseases

Type
Genomic study
Scope
United Kingdom

Why it matters nowThe abstract frames sexually transmissible shigellosis as a public health concern requiring interventions beyond traditional enteric-disease measures. It also highlights antimicrobial stewardship as relevant across pathogens in a syndemic setting.

Social contact patterns in the United Kingdom following the COVID-19 pandemic: The Reconnect cross-sectional survey

Lucy Goodfellow, Billy J. Quilty, Kevin van Zandvoort +1 more

PLOS Medicine

Type
Cross-sectional study
Scope
United Kingdom

Why it matters nowThe study provides empirical post-pandemic contact data to inform mathematical models of respiratory infectious disease transmission, including the incorporation of ethnicity and socioeconomic status.

First use of Trumenba (MenB-fHbp) vaccine to control a nursery outbreak of serogroup B invasive meningococcal disease involving children previously immunised with Bexsero (4CMenB), England, November 2023

Kirsty Foster, Emma J Heymer, Helen Campbell +8 more

Eurosurveillance

Type
Journal article
Scope
United Kingdom

Why it matters nowThe investigation demonstrates the value of pharyngeal swabbing for outbreak strain identification and provides initial safety evidence for off-label use of MenB-fHbp vaccine in young children who had previously received 4CMenB vaccination.

Biosecurity Uptake and Perceived Risk of Avian Influenza Among People in Contact With Birds.

Whitlow H, Gokool S, Clapp G +10 more

Zoonoses and public health

Type
Journal article
Scope
United Kingdom

Why it matters nowThe observed gap between routine animal-focused protocols and human-directed precautions suggests opportunities for targeted educational outreach. Understanding these behavioral patterns can help shape communication strategies that address specific compliance obstacles within high-exposure demographics.

Haemophilus influenzae global epidemiology and antimicrobial susceptibility patterns including ampicillin and amoxicillin-clavulanate resistance based on β-lactamase production, 2013–2022

Maroun M. Sfeir

BMC Infectious Diseases

Type
Journal article
Scope
United Kingdom, United States

Why it matters nowThe findings indicate geographic variation in H. influenzae antimicrobial resistance and differences associated with beta-lactamase production. The authors state that these results support reliable susceptibility testing and resistance-containment efforts, while the abstract reports caution regarding clarithromycin in settings with high resistance.

Systematic review and modelling of Toxoplasma gondii seroprevalence in humans, Europe, 2000 to 2021

Ingrid HM Friesema, Helga Waap, Arno Swart +18 more

Eurosurveillance

Type
Systematic review
Scope
United Kingdom

Why it matters nowToxoplasma gondii infection typically causes mild or asymptomatic illness in immunocompetent individuals but can lead to severe ocular, neurological, or multi-systemic disease and even death in unborn children and immunocompromised persons. The findings establish a robust baseline for future epidemiological research and may support risk assessment studies in Europe.

Peer reviewedOpen accessInfluenzaH5N1Transmission dynamics
DOI 10.2903/j.efsa.2025.9520 ↗

Avian influenza overview March-June 2025.

Alexakis L, Buczkowski H, Ducatez M +11 more

EFSA journal. European Food Safety Authority

Type
Journal article
Scope
Bangladesh, China, United Kingdom

Why it matters nowHuman infections with currently circulating avian A(H5) clade 2.3.4.4b viruses remain rare despite widespread animal circulation; the assessed EU/EEA risk is low for the general public and low-to-moderate for those with occupational exposure to infected animals or contaminated environments.

Avian influenza overview December 2024-March 2025.

Alexakis L, Buczkowski H, Ducatez M +10 more

EFSA journal. European Food Safety Authority

Type
Journal article
Scope
China, United Kingdom, Cambodia

Why it matters nowThe abstract reports that human infections remained infrequent despite circulation in animal populations. It also describes low reported risk for the general public in the EU/EEA and low-to-moderate reported risk for people occupationally or otherwise exposed to infected animals or contaminated environments.

An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 associated with contaminated lettuce and the cascading risks from climate change, the United Kingdom, August to September 2022

Neil Cunningham, Claire Jenkins, Sarah Williams +8 more

Eurosurveillance

Type
Genomic study
Scope
United Kingdom

Why it matters nowThe work demonstrates integration of genomic, epidemiological and environmental data to investigate a large food-borne outbreak and to develop upstream tools that could help prevent future contamination events.

Salmonella and the chicken: reflections on salmonellosis and its control in the United Kingdom

Paul Wigley

Poultry Science and Management

Type
Journal article
Scope
United Kingdom

Why it matters nowMitigating poultry-associated infections remains essential for community safety, although evolving pathogen traits highlight the need for updated mitigation frameworks. Sustained evaluation of control protocols supports ongoing protection against foodborne transmission.

Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-escalation, randomised, controlled, phase 1 trial

Iman Satti, Julia L Marshall, Stephanie A Harris +22 more

The Lancet Infectious Diseases

Type
Randomised controlled trial
Scope
United Kingdom, Bulgaria

Why it matters nowThe paper provides context for tuberculosis vaccine development by describing a controlled human infection model intended for future evaluation of vaccine efficacy and potential correlates of protection. It does not provide evidence about population-level tuberculosis surveillance or current disease activity.

Peer reviewedOpen accessSyphilisAIDSDiagnosticsTreatment
DOI 10.1186/s12879-024-09019-3 ↗

Independent clinic-based evaluation of dual POCTs for screening for HIV and syphilis in men who have sex with men in Italy, Malta, Peru, and the United Kingdom

Nigel Sherriff, Massimo Mirandola, Ronaldo Silva +26 more

BMC Infectious Diseases

Type
Meta-analysis
Scope
Malta, Peru, United Kingdom

Why it matters nowDual point-of-care tests could serve as a cost-effective, patient-friendly, and provider-friendly alternative to conventional testing in clinical and field settings, particularly in resource-limited environments where validated screening tools may help reduce HIV and syphilis incidence.

Transmission dynamics and effect of control measures on the 2022 outbreak of mpox among gay, bisexual, and other men who have sex with men in England: a mathematical modelling study

Xu-Sheng Zhang, Sema Mandal, Hamish Mohammed +8 more

The Lancet Infectious Diseases

Type
Mathematical modelling
Scope
United Kingdom

Why it matters nowThe findings suggest that reductions in sexual partner rates among some GBMSM drove the outbreak reversal, and that timely vaccination helped limit future resurgences, informing control strategies for future mpox outbreaks.

Risk of myocarditis and pericarditis after a COVID-19 mRNA vaccine booster and after COVID-19 in those with and without prior SARS-CoV-2 infection: A self-controlled case series analysis in England

Julia Stowe, Elizabeth Miller, Nick Andrews +1 more

PLOS Medicine

Type
Journal article
Scope
United Kingdom

Why it matters nowThe findings inform COVID-19 vaccination policy by characterizing age- and sex-specific risks of rare cardiac adverse events after booster doses and by demonstrating risk variation by vaccine type and prior infection status. The marked difference in risk between second and third mRNA-1273 doses, which differed in mRNA content, and the lower risk in previously infected individuals provide insights relevant to dosing strategies and immunization schedules.

Air and surface sampling for monkeypox virus in a UK hospital: an observational study

Susan Gould, Barry Atkinson, Okechukwu Onianwa +18 more

The Lancet Microbe

Type
Journal article
Scope
United Kingdom

Why it matters nowThe findings demonstrate environmental contamination in isolation facilities and potential for airborne suspension of monkeypox virus during specific activities such as bedding changes. Contamination of healthcare worker PPE and doffing areas underscores the importance of infection control protocols, proper PPE use, and doffing procedures in preventing nosocomial transmission.

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang, Manoj S. Nair, Lihong Liu +17 more

Nature

Type
Journal article
Scope
United Kingdom, South Africa

Why it matters nowThe abstract frames these variants as relevant to COVID-19 interventions because some authorized and developing therapies and vaccines targeted earlier SARS-CoV-2 forms. The reported neutralization differences are relevant to treatment and vaccination considerations at a population-health level.

Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study

Luke W Meredith, William L Hamilton, Ben Warne +25 more

The Lancet Infectious Diseases

Type
Genomic study
Scope
United Kingdom

Why it matters nowThe abstract describes rapid combined genomic and epidemiological analysis as a tool for investigating suspected health-care-associated COVID-19, detecting otherwise unrecognized transmission events, and identifying opportunities for infection-control action. The findings provide context for genomic epidemiology and outbreak investigation in hospital and community settings, without establishing effects beyond this study.

Peer reviewedOpen accessTyphoid feverParatyphoid feverTreatmentVaccinationAntimicrobial resistance
DOI 10.1371/journal.pntd.0007955 ↗

Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model

Celina Jin, Malick M. Gibani, Shaun H. Pennington +9 more

PLOS Neglected Tropical Diseases

Type
Randomised controlled trial
Scope
United Kingdom

Why it matters nowThe findings are relevant to first-line therapy of uncomplicated enteric fever in the context of emerging antimicrobial resistance, and motivate further work on azithromycin dosing regimens and combination strategies.

Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study

Ibrahim Abubakar, Francis Drobniewski, Jo Southern +44 more

The Lancet Infectious Diseases

Type
Cohort study
Scope
United Kingdom

Why it matters nowOptimizing diagnostic selection for high-risk demographics may enhance resource allocation by prioritizing individuals with demonstrably higher progression probabilities.

Peer reviewedOpen accessRubellaCongenital rubella syndromeSurveillanceVaccinationTreatment
DOI 10.2807/1560-7917.es.2018.23.19.17-00381 ↗

Rubella infection in pregnancy and congenital rubella in United Kingdom, 2003 to 2016

Antoaneta Bukasa, Helen Campbell, Kevin Brown +4 more

Eurosurveillance

Type
Journal article
Scope
United Kingdom

Why it matters nowThe UK achieved WHO elimination status in 2016, with high vaccination uptake and rubella immunity in the population. Most pregnancy infections since 2003 occurred in unvaccinated women and were acquired abroad, suggesting that verification of complete immunization at every healthcare contact remains important.

End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17

Richard Pebody, Fiona Warburton, Joanna Ellis +17 more

Eurosurveillance

Type
Case-control study
Scope
United Kingdom

Why it matters nowThese results bolster the rationale for sustaining youth immunization initiatives while underscoring the continued necessity of developing robust protective strategies for elderly populations.

Measles outbreak linked to European B3 outbreaks, Wales, United Kingdom, 2017

Jonny Currie, Llion Davies, Joanne McCarthy +7 more

Eurosurveillance

Type
Journal article
Scope
United Kingdom

Why it matters nowThe outbreak occurred after the United Kingdom had achieved interrupted endemic measles transmission for 36 months in 2016, illustrating the ongoing risk of imported measles cases.

Passive enhanced safety surveillance for Vaxigrip and Intanza 15 µg in the United Kingdom and Finland during the northern hemisphere influenza season 2015/16

Hélène Bricout, Anne Laure Chabanon, Audrey Souverain +3 more

Eurosurveillance

Type
Journal article
Scope
Finland, United Kingdom

Why it matters nowThe passive enhanced safety surveillance demonstrated improved data reporting and showed suitability to health authority requirements for near real-time detection of potential increases in vaccine reactogenicity following annual influenza strain updates.

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

Katie Ewer, Tommy Rampling, Navin Venkatraman +53 more

New England Journal of Medicine

Type
Journal article
Scope
Democratic Republic of the Congo, United Kingdom

Why it matters nowDevelopment of an effective Ebola vaccine was identified as a priority for controlling future outbreaks following the West African epidemic that caused over 11,000 deaths.