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疾病概览

细菌性

产志贺毒素大肠杆菌感染

Shiga toxin-producing Escherichia coli infection

有证据支持的资料英文 5/7 个适用章节 · 中文 5/7 个适用章节更新于 2026年9月3日

产志贺毒素大肠杆菌(STEC)感染是儿童溶血性尿毒综合征(HUS)的主要原因,具有显著暴发潜力 [1]。HUS 被归类为血栓性微血管病,通常分为典型(由 STEC 引起)、非典型(补体激活失调)或继发于其他疾病 [2]

阅读完整临床与流行病学资料6
定义

STEC 感染通过释放志贺毒素诱导微血管内皮细胞发生血栓形成和炎症级联反应 [1]。HUS 定义为机械性溶血性贫血、血小板减少和急性肾损伤的三联征 [1]。非典型 HUS 主要与导致补体激活失调的突变或自身抗体相关 [2]

临床特征

主要临床表现为腹泻,其中约 60% 的患者出现血便,中位潜伏期约为三天 [1]。在 5% 至 15% 的 STEC 感染病例中可发展为 HUS [1]

流行病学

自 2010 年代初以来,STEC 流行病学特征表现为历史上占主导地位的 O157 血清群下降,非 O157 STEC(特别是 O26 和 O80)出现 [1]。该病原体具有重大暴发潜力 [1]

传播/暴露

污染主要通过摄入受污染的食物或水发生 [1]。此外,存在人与人之间的传播途径 [1]。接触反刍动物或其受污染的环境也是重要的传播方式 [1]

预防

不建议在 STEC 感染个体中使用抗生素,因为证据表明其可能与溶血性尿毒综合征的发展风险增加相关 [3]。某些天然胶多糖分可能具有调节肠道菌群和保护作用,但需进一步研究 [4]

参考文献
  1. 1Bruyand M et al. Hemolytic uremic syndrome due to Shiga toxin-producing Escherichia coli infection. Med Mal Infect. 2018 May. PMID: 29054297. doi: 10.1016/j.medmal.2017.09.012.PubMed: https://pubmed.ncbi.nlm.nih.gov/29054297/
  2. 2Freedman SB et al. Shiga Toxin-Producing Escherichia coli Infection, Antibiotics, and Risk of Developing Hemolytic Uremic Syndrome: A Meta-analysis. Clin Infect Dis. 2016 May 15. PMID: 26917812. doi: 10.1093/cid/ciw099.PubMed: https://pubmed.ncbi.nlm.nih.gov/26917812/
  3. 3Jokiranta TS et al. HUS and atypical HUS. Blood. 2017 May 25. PMID: 28416508. doi: 10.1182/blood-2016-11-709865.PubMed: https://pubmed.ncbi.nlm.nih.gov/28416508/
  4. 4Mortari G et al. Shiga toxin-producing Escherichia coli infection as a precipitating factor for atypical hemolytic-uremic syndrome. Pediatr Nephrol. 2025 Feb. PMID: 39347991. doi: 10.1007/s00467-024-06480-9.PubMed: https://pubmed.ncbi.nlm.nih.gov/39347991/
  5. 5Chaves LS et al. Cashew gum fractions protect intestinal mucosa against shiga toxin-producing Escherichia coli infection: Characterization and insights into microbiota modulation. Int J Biol Macromol. 2025 Jun. PMID: 40324507. doi: 10.1016/j.ijbiomac.2025.143916.PubMed: https://pubmed.ncbi.nlm.nih.gov/40324507/
编码登记
ICD-10
A04.3
ICD-11
1A03
核心统计
累计病例
302K
峰值月份
2026-08
覆盖区间
40 个报告国家 · 1991-01-01 → 2026-09-01

数据覆盖

报告国家和地区

40 个国家/地区

月度变化趋势

数据获取

本页面数据索引,含来源链接和更新信息。

行数5,189
更新2026-09-01
范围
分块8
来源37 序列 · 1,207 观测
官方数据来源机构、频率与说明54
Austria

Austria AGES Radar for Infectious Diseases

Austria

来源
每月official_monthly_csv

AGES Radar monthly national source. Internal ingestion retains native categories; public release is disabled pending licence review.

Australia

Australia NINDSS

Australia

来源
每月Power BI 看板

Australian national notifiable diseases surveillance dashboard.

Australian Capital Territory, Australia

Australia NINDSS — Australian Capital Territory

Australian Capital Territory, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.

New South Wales, Australia

Australia NINDSS — New South Wales

New South Wales, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for New South Wales, kept separate from the Australia national aggregate.

Northern Territory, Australia

Australia NINDSS — Northern Territory

Northern Territory, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.

Queensland, Australia

Australia NINDSS — Queensland

Queensland, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.

South Australia, Australia

Australia NINDSS — South Australia

South Australia, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for South Australia, kept separate from the Australia national aggregate.

Tasmania, Australia

Australia NINDSS — Tasmania

Tasmania, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.

Victoria, Australia

Australia NINDSS — Victoria

Victoria, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.

Western Australia, Australia

Australia NINDSS — Western Australia

Western Australia, Australia

来源
每月Power BI 看板

Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.

Belgium

ECDC Surveillance Atlas — Belgium Annual Baseline

Belgium

来源
每年official_ecdc_rest_aggregate

Belgium annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Bulgaria

ECDC Surveillance Atlas — Bulgaria Annual Baseline

Bulgaria

来源
每年official_ecdc_rest_aggregate

Bulgaria annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Canada

Canada PHAC CNDSS Annual

Canada

来源
ANNUAL网页

Canada is the national jurisdiction; subdivision feeds are registered separately.

Ontario, Canada

Public Health Ontario IDTO Monthly

Ontario, Canada

来源
每月Power BI 看板

Ontario-level current-year preliminary monthly case counts from Public Health Ontario's IDTO report.

Switzerland

Switzerland FOPH IDD

Switzerland

来源
每周rest_api

Switzerland FOPH/BAG IDD mandatory reporting API normalized to national case rows. Monthly series may use the dashboard CHFL aggregate where CH-only monthly series are not exposed.

Cyprus

ECDC Surveillance Atlas — Cyprus Annual Baseline

Cyprus

来源
每年official_ecdc_rest_aggregate

Cyprus annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Czechia

ECDC Surveillance Atlas — Czechia Annual Baseline

Czechia

来源
每年official_ecdc_rest_aggregate

Czechia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Germany

Germany RKI SurvStat 2.0

Germany

来源
每周official_webforms_csv_export

RKI SurvStat national weekly notification export; raw ZIP exports are retained and recent weeks are overwritten for revisions.

Denmark

ECDC Surveillance Atlas — Denmark Annual Baseline

Denmark

来源
每年official_ecdc_rest_aggregate

Denmark annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Estonia

ECDC Surveillance Atlas — Estonia Annual Baseline

Estonia

来源
每年official_ecdc_rest_aggregate

Estonia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Spain

ECDC Surveillance Atlas — Spain Annual Baseline

Spain

来源
每年official_ecdc_rest_aggregate

Spain annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Finland

Finland THL Infectious Diseases Register

Finland

来源
每月cube_csv

Finland THL Infectious Diseases Register national monthly case counts. The current month is ingested as provisional and the latest three months are refreshed for source revisions.

France

ECDC Surveillance Atlas — France Annual Baseline

France

来源
每年official_ecdc_rest_aggregate

France annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

United Kingdom

ECDC Surveillance Atlas — United Kingdom Annual Baseline

United Kingdom

来源
每年official_ecdc_rest_aggregate

United Kingdom annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Greece

ECDC Surveillance Atlas — Greece Annual Baseline

Greece

来源
每年official_ecdc_rest_aggregate

Greece annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Hong Kong, China

Hong Kong, China CHP Notifiable Diseases

Hong Kong, China

来源
每月开放数据

Hong Kong, China CHP annual notifiable infectious disease CSVs normalized to national monthly totals

Croatia

ECDC Surveillance Atlas — Croatia Annual Baseline

Croatia

来源
每年official_ecdc_rest_aggregate

Croatia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Hungary

ECDC Surveillance Atlas — Hungary Annual Baseline

Hungary

来源
每年official_ecdc_rest_aggregate

Hungary annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Ireland

Ireland HPSC Notifiable Diseases Hub

Ireland

来源
每周official_arcgis_feature_service

Ireland HPSC national weekly notifiable-disease totals from the official ArcGIS FeatureServer. Internal ingestion is enabled; public release remains disabled pending written redistribution permission.

Iceland

冰岛卫生署年度传染病看板

Iceland

来源
每年Power BI 看板

冰岛全国分病种年度病例通报;历史值可能追溯修订,并保持年度总量口径。

Iceland

冰岛卫生署性病监测看板

Iceland

来源
月度事实(按季度发布)Power BI 看板

实验室与登记监测的月度性病诊断事实;官方看板按季度发布。

Iceland

冰岛卫生署呼吸道感染周度看板

Iceland

来源
每周Power BI 看板

按 ISO 周记录的呼吸道疾病诊断数;住院、样本和疫苗指标不计入诊断数。

Iceland

冰岛卫生署历史传染病登记

Iceland

来源
年度与月度官方 Excel

1997—2021 年官方历史登记表,年度与月度事实按原始粒度保留。

Iceland

冰岛卫生署历史 ICD 临床月报

Iceland

来源
每月官方 Excel

Saga 电子病历 ICD 就诊数;与登记通报不可比并保持独立。

Italy

ECDC Surveillance Atlas — Italy Annual Baseline

Italy

来源
每年official_ecdc_rest_aggregate

Italy annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Japan

日本 NIID/JIHS 周报

Japan

来源
每周网页

日本 NIID/JIHS 周度传染病监测数据。

South Korea

Korea KDCA EID

South Korea

来源
每月open_api_or_portal_download

Korea KDCA notifiable infectious disease OpenAPI or portal/KOSIS downloads aggregated to national monthly notification counts.

Liechtenstein

ECDC Surveillance Atlas — Liechtenstein Annual Baseline

Liechtenstein

来源
每年official_ecdc_rest_aggregate

Liechtenstein annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Lithuania

ECDC Surveillance Atlas — Lithuania Annual Baseline

Lithuania

来源
每年official_ecdc_rest_aggregate

Lithuania annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Luxembourg

ECDC Surveillance Atlas — Luxembourg Annual Baseline

Luxembourg

来源
每年official_ecdc_rest_aggregate

Luxembourg annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Latvia

ECDC Surveillance Atlas — Latvia Annual Baseline

Latvia

来源
每年official_ecdc_rest_aggregate

Latvia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Malta

ECDC Surveillance Atlas — Malta Annual Baseline

Malta

来源
每年official_ecdc_rest_aggregate

Malta annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Netherlands

ECDC Surveillance Atlas — Netherlands Annual Baseline

Netherlands

来源
每年official_ecdc_rest_aggregate

Netherlands annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Norway

Norway FHI MSIS Statistics Bank

Norway

来源
每月official_json_api

Norway FHI MSIS national monthly notifications from the official Allvis frontend API; adapter contract checks guard the unversioned endpoint.

New Zealand

New Zealand PHF Science Monthly Notifiable Diseases

New Zealand

来源
每月网页

PHF Science (formerly ESR) monthly notifiable disease surveillance data via internal globalID2 crawler

Poland

ECDC Surveillance Atlas — Poland Annual Baseline

Poland

来源
每年official_ecdc_rest_aggregate

Poland annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Portugal

ECDC Surveillance Atlas — Portugal Annual Baseline

Portugal

来源
每年official_ecdc_rest_aggregate

Portugal annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Romania

ECDC Surveillance Atlas — Romania Annual Baseline

Romania

来源
每年official_ecdc_rest_aggregate

Romania annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Sweden

Sweden Public Health Agency SmiNet

Sweden

来源
每月official_html_csv

Sweden SmiNet national monthly reported cases from the official Public Health Agency statistics pages; public release is enabled with closed-month publication and revisable recent-month refreshes.

Slovenia

ECDC Surveillance Atlas — Slovenia Annual Baseline

Slovenia

来源
每年official_ecdc_rest_aggregate

Slovenia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Slovakia

ECDC Surveillance Atlas — Slovakia Annual Baseline

Slovakia

来源
每年official_ecdc_rest_aggregate

Slovakia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.

Taiwan, China

Taiwan, China CDC NIDSS

Taiwan, China

来源
每月开放数据

Taiwan, China monthly notifiable infectious disease open-data CSV feed.

United States

US CDC NNDSS

United States

来源
mixed_weekly_annual接口

CDC National Notifiable Diseases Surveillance System provisional data.

United States

US CDC NHSS HIV

United States

来源
mixed_weekly_annual接口

CDC NNDSS weekly data plus NHSS annual national HIV diagnoses

分块公开数据

选择时间范围和格式