弧菌病是指由非霍乱弧菌属细菌(主要包括副溶血弧菌、溶藻弧菌和创伤弧菌等)引起的感染性疾病,与霍乱弧菌导致的霍乱相区别[1]。弧菌属细菌广泛存在于各种水生和海洋环境中,约12种弧菌可对人类致病[1]。在养殖业领域,弧菌病也被视为由弧菌属细菌引起的一类重要细菌性疾病,常对抗生素表现出耐药性[2]。
疾病概览
细菌性弧菌病
Vibriosis
弧菌病(vibriosis)是由非霍乱弧菌属细菌引起的一类感染,主要涉及副溶血弧菌、溶藻弧菌和创伤弧菌等菌种,可表现为胃肠道或伤口感染等多种临床表现[1]。该病在沿海和水产养殖环境中尤为突出,是水产养殖业面临的主要威胁之一[2]。南亚地区的系统综述显示,非霍乱弧菌在腹泻患者中具有较高的分离率,表明该病在该区域造成显著疾病负担[3]。全球范围内,弧菌病的发病率呈上升趋势,部分原因可能与气候变化及海水温度升高对弧菌分布的影响有关[1]。
阅读完整临床与流行病学资料6
弧菌属细菌感染在临床表现上呈现疾病特异性差异。霍乱弧菌(Vibrio cholerae)感染可引发霍乱,这是一种严重的腹泻性疾病,若不及时治疗可迅速致命。多数非霍乱弧菌感染(包括副溶血弧菌V. parahaemolyticus、溶藻弧菌V. alginolyticus及创伤弧菌V. vulnificus)所致弧菌病(vibriosis)通常表现为轻度、自限性的胃肠炎。然而,创伤弧菌作为一种机会性致病菌,可导致伤口感染并迅速进展为败血症,具有较高死亡率。临床治疗需依据病原体而定:霍乱以补液治疗为主,创伤弧菌伤口感染需进行感染组织清创,严重霍乱及系统性感染则需抗生素治疗[1]。
弧菌属细菌广泛存在于多种水生及海洋环境中,已描述的弧菌种类超过100种,其中约12种可引起人类感染[1]。南亚地区仍是非霍乱弧菌感染的高负担区域,相关食物源性疾病持续存在。一项截至2023年5月的系统综述和荟萃分析纳入了38项研究(其中22项进入荟萃分析),显示腹泻患者中非霍乱弧菌的总合并分离率为4.0%(95%CI 3.0-5.0%),其中非O1/非O139型霍乱弧菌分离率为9.0%(95%CI 7.0-10.0%),副溶血弧菌为1.0%(95%CI 1.0-2.0%),河弧菌(V. fluvialis)为2.0%(95%CI 1.0-3.0%);副溶血弧菌以O3:K6血清型最为常见,病例在夏季达到高峰。近年弧菌病发病率呈上升趋势,部分原因可能与气候变化及海水温度升高促进弧菌扩散有关[1]。
非霍乱弧菌的感染途径主要包括暴露于海水以及食用生的或未煮熟的受污染海产品[1]。霍乱弧菌则通常通过受污染的水源以及人与人之间的接触传播[1]。南亚地区的研究表明,食物是重要的传播媒介,多种弧菌血清型与食源性感染密切相关[3]。
弧菌病的预防主要依赖于食品安全和卫生措施,包括避免食用生的或未煮熟的海产品,以及减少开放性伤口接触海水的机会[1]。在霍乱防控方面,可通过口服霍乱疫苗获得有效保护,同时确保饮用水安全和环境卫生[1]。在水产养殖领域,由于弧菌对抗生素的耐药性问题日益突出,细菌素(bacteriocins)等替代性防控措施因其窄谱活性而受到关注[2]。研究显示,弧菌素(vibriocins)对包括溶藻弧菌、哈维弧菌和副溶血弧菌等高致病性菌株具有抑制作用,可作为有针对性的弧菌病防控手段[2]。
- 1Baker-Austin C et al. Vibrio spp. infections. Nat Rev Dis Primers. 2018 Jul 12. PMID: 30002421. doi: 10.1038/s41572-018-0005-8.PubMed: https://pubmed.ncbi.nlm.nih.gov/30002421/
- 2Muzembo BA et al. Vibriosis in South Asia: A systematic review and meta-analysis. Int J Infect Dis. 2024 Apr. PMID: 38311027. doi: 10.1016/j.ijid.2024.01.022.PubMed: https://pubmed.ncbi.nlm.nih.gov/38311027/
- 3Sheikh H et al. Vibrio spp. and Their Vibriocin as a Vibriosis Control Measure in Aquaculture. Appl Biochem Biotechnol. 2022 Oct. PMID: 35451794. doi: 10.1007/s12010-022-03919-3.PubMed: https://pubmed.ncbi.nlm.nih.gov/35451794/
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官方数据来源机构、频率与说明14
Australia NINDSS
Australia
Australian national notifiable diseases surveillance dashboard.
Australia NINDSS — Australian Capital Territory
Australian Capital Territory, Australia
Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.
Australia NINDSS — New South Wales
New South Wales, Australia
Australian NINDSS monthly state/territory notifications for New South Wales, kept separate from the Australia national aggregate.
Australia NINDSS — Northern Territory
Northern Territory, Australia
Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Queensland
Queensland, Australia
Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.
Australia NINDSS — South Australia
South Australia, Australia
Australian NINDSS monthly state/territory notifications for South Australia, kept separate from the Australia national aggregate.
Australia NINDSS — Tasmania
Tasmania, Australia
Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.
Australia NINDSS — Victoria
Victoria, Australia
Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.
Australia NINDSS — Western Australia
Western Australia, Australia
Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.
Korea KDCA EID
South Korea
Korea KDCA notifiable infectious disease OpenAPI or portal/KOSIS downloads aggregated to national monthly notification counts.
Norway FHI MSIS Statistics Bank
Norway
Norway FHI MSIS national monthly notifications from the official Allvis frontend API; adapter contract checks guard the unversioned endpoint.
Sweden Public Health Agency SmiNet
Sweden
Sweden SmiNet national monthly reported cases from the official Public Health Agency statistics pages; public release is enabled with closed-month publication and revisable recent-month refreshes.
US CDC NNDSS
United States
CDC National Notifiable Diseases Surveillance System provisional data.
US CDC NHSS HIV
United States
CDC NNDSS weekly data plus NHSS annual national HIV diagnoses