Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins
Vaccine·
- DOI
- 10.1016/j.vaccine.2006.04.021
- PMID
- 16701924
- PMCID
- —
- OpenAlex
- W2071190141
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The paper is relevant to understanding why Hib vaccine responses may differ between populations and why some vaccinated individuals may have weaker antibody responses. It is an immunogenicity study rather than a direct assessment of disease burden.
Structured evidence summary
Research question
To assess whether genetic and environmental factors influence immune response to Hib conjugate vaccine in Gambian twins.
Study design
Twin study measuring serum anti-PRP antibody in monozygotic and dizygotic twin pairs, with intrapair correlation and heritability analysis.
Population and setting
43 monozygotic and 147 dizygotic twin pairs from the Gambia.
Main findings
Heritability of antibody response to Hib conjugate vaccine was estimated at 51% (95% CI 32-66%), which the abstract describes as a significant genetic contribution. The authors also state that genetic factors may help explain variation in vaccine response across populations and may contribute to vaccine failure cases.
Public-health relevance
The paper is relevant to understanding why Hib vaccine responses may differ between populations and why some vaccinated individuals may have weaker antibody responses. It is an immunogenicity study rather than a direct assessment of disease burden.
Important limitations
No explicit limitations are stated in the abstract. Interpretation is limited to the supplied single-article abstract and metadata, and the original paper would be needed for decision-grade assessment; the reported outcome is antibody response in twins rather than clinical Hib disease outcomes.
GIDS interpretation
The article is discoverable as a peer-reviewed 2006 vaccine study from The Gambia focused on Hib immunogenicity in twins. It provides context about host-response variation, but the supplied record does not support treating it as evidence of a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 15 auditable classifier relationships to diseases, places, topics, and study design.