Nipah virus infection: A review
Epidemiology and Infection·
- DOI
- 10.1017/s0950268819000086
- PMID
- 30869046
- PMCID
- PMC6518547
- OpenAlex
- W2977314956
- Study type
- Journal article
- Publisher
- Cambridge University Press (CUP)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The high mortality, potential for geographic spread, community transmission, and lack of effective countermeasures underscore the public health importance of Nipah virus. A One Health approach is necessary for prevention and control given bat-to-human transmission chains.
Structured evidence summary
Research question
This review synthesizes knowledge on Nipah virus infection, covering its emergence, clinical and epidemiological features, diagnosis, and the need for effective management and control strategies.
Study design
This is a narrative review article summarizing existing knowledge on Nipah virus infection.
Population and setting
The review addresses Nipah virus outbreaks that have occurred in South and Southeast Asia, with the virus first identified in Malaysia 20 years prior to publication.
Main findings
Nipah virus causes severe neurological and respiratory disease with high lethality and transmits through infected animals or people. Different virus strains exhibit varying clinical and epidemiological characteristics. Rapid diagnosis and infection control are critical for outbreak containment, though no effective treatment or prophylaxis is readily available.
Public-health relevance
The high mortality, potential for geographic spread, community transmission, and lack of effective countermeasures underscore the public health importance of Nipah virus. A One Health approach is necessary for prevention and control given bat-to-human transmission chains.
Important limitations
This summary is limited to the supplied single-article abstract and metadata. The original paper is required for decision-grade interpretation of the review's scope, methodology, and evidence synthesis approach.
GIDS interpretation
This peer-reviewed review article would be discoverable in literature surveillance systems through its disease, geographic, and topic classifiers, providing context on Nipah virus epidemiology, diagnosis, and control measures relevant to outbreak preparedness.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 15 auditable classifier relationships to diseases, places, topics, and study design.