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Peer reviewedOpen accessSARSCOVID-19

Mitigation of SARS-CoV-2 transmission at a large public university

Nature Communications·

Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Richard L. Fredrickson, Tong Wang, George N. Wong, Johnny Uelmen, Sergei Maslov, Zachary J. Weiner, Alexei V. Tkachenko, Hantao Zhang, Zhiru Liu, Ahmed Ibrahim, Sanjay J. Patel, John M. Paul, Nickolas P. Vance, Joseph G. Gulick, Sandeep Puthanveetil Satheesan, Isaac J. Galvan, Andrew Miller, Joseph Grohens, Todd J. Nelson, Mary P. Stevens, P Mark Hennessy, Robert C. Parker, Edward Santos, Charles Brackett, Julie D. Steinman, Melvin R. Fenner, Kirstin Dohrer, Michael DeLorenzo, Laura Wilhelm-Barr, Brian R. Brauer, Catherine Best-Popescu, Gary Durack, Nathan Wetter, David M. Kranz, Jessica Breitbarth, Charlie Simpson, Julie A. Pryde, Robin N. Kaler, Chris Harris, Allison C. Vance, Jodi L. Silotto, Mark Johnson, Enrique Andres Valera, Patricia K. Anton, Lowa Mwilambwe, Stephen P. Bryan, Deborah S. Stone, Danita B. Young, Wanda E. Ward, John Lantz, John A. Vozenilek, Rashid Bashir, Jeffrey S. Moore, Mayank Garg, Julian C. Cooper, Gillian Snyder, Michelle H. Lore, Dustin L. Yocum, Neal J. Cohen, Jan E. Novakofski, Melanie J. Loots, Randy L. Ballard, Mark Band, Kayla M. Banks, Joseph D. Barnes, Iuliana Bentea, Jessica Black, Jeremy Busch, Abigail Conte, Madison Conte, Michael Curry, Jennifer Eardley, April Edwards, Therese Eggett, Judes Fleurimont, Delaney Foster, Bruce W. Fouke, Nicholas Gallagher, Nicole Gastala, Scott A. Genung, Declan Glueck, Brittani Gray, Andrew Greta, Robert M. Healy, Ashley Hetrick, Arianna A. Holterman, Nahed Ismail, Ian Jasenof, Patrick Kelly, Aaron Kielbasa, Teresa Kiesel, Lorenzo M. Kindle, Rhonda L. Lipking, Yukari C. Manabe, Jade ́ Mayes, Reubin McGuffin, Kenton G. McHenry, Agha Mirza, Jada Moseley, Heba H. Mostafa, Melody Mumford, Kathleen Munoz, Arika D. Murray, Moira Nolan, Nil A. Parikh, Andrew Pekosz, Janna Pflugmacher, Janise M. Phillips, Collin Pitts, Mark C. Potter, James Quisenberry, Janelle Rear, Matthew L. Robinson, Edith Rosillo, Leslie N. Rye, MaryEllen Sherwood, Anna Simon, Jamie M. Singson, Carly Skadden, Tina H. Skelton, Charlie Smith, Mary Stech, Ryan Thomas, Matthew A. Tomaszewski, Erika A. Tyburski, Scott Vanwingerden, Evette Vlach, Ronald S. Watkins, Karriem Watson, Karen C. White, Timothy L. Killeen, Robert J. Jones, Andreas C. Cangellaris, Susan A. Martinis, Awais Vaid, Christopher B. Brooke, Joseph T. Walsh, Ahmed Elbanna, William C. Sullivan, Rebecca L. Smith, Nigel Goldenfeld, Timothy M. Fan, Paul J. Hergenrother, Martin D. Burke

DOI
10.1038/s41467-022-30833-3
PMID
35680861
PMCID
PMC9184485
OpenAlex
W4281637680
Study type
Journal article
Publisher
Springer Science and Business Media LLC
Article type
journal-article
Integrity
current

Why this research matters now

The program demonstrates that frequent testing paired with non-pharmaceutical interventions can sustain in-person university instruction while protecting both campus and surrounding community health. The scalable, low-cost testing approach may inform institutional mitigation strategies.

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Structured evidence summary

Research question

The study examines whether a multimodal intervention program combining frequent saliva-based testing, epidemiological modeling, and digital communication tools can mitigate SARS-CoV-2 transmission in a large university setting.

Study design

This is a case study implemented at the University of Illinois at Urbana-Champaign during Fall 2020. The intervention included a novel saliva-based RT-qPCR assay bypassing RNA extraction, epidemiological modeling and surveillance, and digital compliance tools.

Population and setting

The study population consisted of the university community at a large public university during the Fall 2020 semester. Over one million tests were performed within this population.

Main findings

Positivity rates remained low throughout the Fall 2020 semester. The university community experienced zero COVID-19-related hospitalizations or deaths. Mortality in the surrounding Champaign County was reduced more than fourfold relative to expected levels.

Public-health relevance

The program demonstrates that frequent testing paired with non-pharmaceutical interventions can sustain in-person university instruction while protecting both campus and surrounding community health. The scalable, low-cost testing approach may inform institutional mitigation strategies.

Important limitations

This summary relies on the supplied single-article abstract and metadata. The case study design limits generalizability, and assessment of causality, confounding factors, comparator institutions, and detailed cost-effectiveness requires review of the full paper.

GIDS interpretation

The article was classified under diagnostics, outbreak investigation, surveillance, and transmission dynamics topics for COVID-19 and SARS. This classification aids discoverability within GIDS for users examining university-based mitigation programs or saliva-based testing innovations during the pandemic period.

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Related GIDS surveillance

Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.

03

Evidence relationships

This article has 11 auditable classifier relationships to diseases, places, topics, and study design.

about diseaseabout diseaseaddresses topicaddresses topicaddresses topicaddresses topicevaluates interventionhas pathogen typestudied population settingstudies pathogenuses study design