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Peer reviewedHistorical baselineMeasles

Studies on an attenuated measles-virus vaccine. VI. Clinical, antigenic and prophylactic effects of vaccine in institutionalized children.

The New England journal of medicine·

Krugman S, Giles JP, Jacobs AM

DOI
10.1056/nejm196007282630406
PMID
14412241
PMCID
OpenAlex
Study type
Journal article
Publisher
Publisher unavailable
Article type
journal-article
Integrity
current

Why this research matters now

A pre-MMR measles vaccine study that anchors long-run vaccine-preventable disease context.

01

Structured evidence summary

Research question

How did an attenuated measles-virus vaccine perform clinically and immunologically in children?

Study design

Early clinical vaccine study.

Population and setting

Institutionalized children in the United States.

Main findings

This field has not yet received a quality-gated evidence summary. Consult the original article.

Public-health relevance

Provides historical context for measles vaccination evidence before modern elimination programs.

Important limitations

Limitations could not be fully assessed from the available metadata.

GIDS interpretation

Use as background for vaccine-era measles surveillance, not as current clinical guidance.

02

Related GIDS surveillance

Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.

03

Evidence relationships

This article has 7 auditable classifier relationships to diseases, places, topics, and study design.

about diseaseaddresses topicaddresses topicevaluates interventionstudied instudied population settinguses study design