Elevated Risk for Antimicrobial Drug–Resistant Shigella Infection among Men Who Have Sex with Men, United States, 2011–2015
Emerging Infectious Diseases·
- DOI
- 10.3201/eid2209.160624
- PMID
- 27533624
- PMCID
- PMC4994375
- OpenAlex
- W2506822949
- Study type
- Journal article
- Publisher
- Centers for Disease Control and Prevention (CDC)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The data underscore the importance of integrating sexual history assessments into routine clinical evaluations and public health investigations for enteric pathogens. Tailored educational outreach appears necessary for populations experiencing elevated resistance rates.
Structured evidence summary
Research question
The investigation examined whether specific transmission pathways correlate with varying patterns of antimicrobial resistance in reported shigellosis outbreaks across the United States.
Study design
This research utilized an observational cluster analysis framework to evaluate shigellosis outbreak data collected over a five-year timeframe.
Population and setting
The analysis focused on categorized shigellosis clusters within the United States, distinguishing between cohorts associated with men who have sex with men and other transmission groups.
Main findings
Antimicrobial resistance was detected in nearly all clusters involving men who have sex with men, whereas it appeared in a minority of other groups. Azithromycin resistance demonstrated a markedly higher frequency within the former cohort. Several clusters exhibited resistance to multiple tested medications simultaneously.
Public-health relevance
The data underscore the importance of integrating sexual history assessments into routine clinical evaluations and public health investigations for enteric pathogens. Tailored educational outreach appears necessary for populations experiencing elevated resistance rates.
Important limitations
The provided abstract does not outline specific methodological constraints or statistical power calculations. Accordingly, this assessment depends entirely on the supplied abstract and metadata, necessitating the complete manuscript for rigorous appraisal.
GIDS interpretation
This record offers historical epidemiological context concerning resistance distribution and transmission categorization during a specified past period. It functions as a reference document for tracking temporal trends rather than reflecting ongoing monitoring activities.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.