Burden of Shigella infection in children under five years living in a peri-urban area of Ouagadougou, Burkina Faso: A community-based cohort study
PLOS Neglected Tropical Diseases·
- DOI
- 10.1371/journal.pntd.0014624
- PMID
- —
- PMCID
- —
- OpenAlex
- W7203446033
- Study type
- Cohort study
- Publisher
- Public Library of Science (PLoS)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Regional incidence estimates and strain distributions offer foundational parameters for evaluating pediatric immunization strategies and directing sanitation resource allocation.
Structured evidence summary
Research question
What is the measured frequency and strain composition of Shigella colonization and disease among preschool-aged residents in a peri-urban district of Burkina Faso, and which environmental or demographic variables correlate with detection?
Study design
Investigators implemented a twelve-month longitudinal community cohort utilizing combined active and passive monitoring windows to track pediatric participants across multiple follow-up intervals.
Population and setting
The enrolled sample comprised seven hundred fifty individuals younger than five years old situated in a peri-urban locality near Ouagadougou, Burkina Faso.
Main findings
Analysis revealed an overall detection rate of 6.8 occurrences per thousand child-months, with mucoid stool presentations predominating over bloody variants. Elevated detection probabilities were observed in toddlers aged twelve to twenty-three months and preschoolers aged thirty-six to forty-seven months, while municipal water utilization corresponded with lower occurrence rates. Asymptomatic colonization was recorded at nearly five cases per thousand child-months, and Shigella flexneri represented the majority of identified isolates.
Public-health relevance
Regional incidence estimates and strain distributions offer foundational parameters for evaluating pediatric immunization strategies and directing sanitation resource allocation.
Important limitations
The current assessment depends entirely on the supplied abstract and bibliographic records, requiring examination of the complete manuscript to verify methodological details and support definitive analytical conclusions.
GIDS interpretation
This report supplies localized epidemiological context regarding pathogen prevalence and host characteristics within the referenced geographic zone, aiding systematic literature mapping and topic classification workflows.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.