ESBL-Producing and Macrolide-Resistant Shigella sonnei Infections among Men Who Have Sex with Men, England, 2015
Emerging Infectious Diseases·
- DOI
- 10.3201/eid2211.160653
- PMID
- 27767929
- PMCID
- PMC5088027
- OpenAlex
- W2525041715
- Study type
- Genomic study
- Publisher
- Centers for Disease Control and Prevention (CDC)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings document emergence of multidrug-resistant S. sonnei with combined ESBL production and macrolide resistance in a population at elevated risk for shigellosis transmission. The plasmid-mediated resistance and mobile genetic element acquisition suggest potential for ongoing resistance spread.
Structured evidence summary
Research question
The study investigated antimicrobial resistance patterns and genetic relatedness of Shigella sonnei isolates from men who have sex with men in England during 2015.
Study design
This genomic study used whole-genome sequencing to characterize S. sonnei isolates and assess their genetic relationships.
Population and setting
The study focused on men who have sex with men with shigellosis in England during 2015.
Main findings
S. sonnei isolates produced extended-spectrum β-lactamases and demonstrated macrolide resistance. Genomic analysis revealed close genetic relatedness among isolates, which carried a plasmid previously linked to an outbreak in this population that had acquired an additional mobile element.
Public-health relevance
The findings document emergence of multidrug-resistant S. sonnei with combined ESBL production and macrolide resistance in a population at elevated risk for shigellosis transmission. The plasmid-mediated resistance and mobile genetic element acquisition suggest potential for ongoing resistance spread.
Important limitations
This summary relies on the supplied single-article abstract and metadata. Full assessment of study limitations, including sample size, representativeness, temporal scope, and sequencing depth, requires review of the complete published article.
GIDS interpretation
This article is discoverable through antimicrobial resistance, genomic epidemiology, and outbreak investigation topics, as well as shigellosis and dysentery disease classifiers. These links reflect the study's subject matter and do not indicate an active surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.