急性丙型肝炎指丙型肝炎病毒感染后的早期临床阶段,通常以新近获得病毒血症为特征[2]。该阶段是疾病自然史的关键节点,若病毒持续存在超过六个月则界定为慢性感染[2]。作为全球主要的肝脏疾病病因之一,急性期感染不仅直接关联肝硬化、肝癌及相关死亡风险,也对医疗系统构成显著负担[2]。
疾病概览
急性丙型肝炎
Acute hepatitis C
急性丙型肝炎病毒(HCV)感染是全球公共卫生的重要关切,其发病率存在显著的地理差异[1]。该疾病处于丙型肝炎演变的早期阶段,多数患者病程相对有利,但仍有约半数至七成个体在六个月内发展为慢性感染[2]。由于缺乏预防性疫苗且诊断存在特定挑战,早期识别与公共卫生干预对控制传播及降低肝病负担至关重要[1][2]。
阅读完整临床与流行病学资料6
急性期感染的临床表现常因宿主免疫状态及既往感染史而呈现异质性[1]。在免疫功能低下、再次感染或重叠感染的个体中,由于难以准确捕捉抗-HCV抗体血清转换及病毒核酸的动态变化,确诊往往面临较大挑战[1]。尽管多数病例初期病程较为平稳,但该阶段仍是阻断疾病向慢性化进展及减少后续并发症发生的核心窗口期[2]。
急性丙型肝炎的流行特征呈现明显的地域分布差异,整体发病率在全球范围内波动较大[1]。不安全医疗操作、注射毒品行为及人类免疫缺陷病毒感染者被报告为最易感群体,凸显其分布与高风险暴露因素的紧密关联[1]。
丙型肝炎病毒(HCV)感染仍然是一个重大的公共卫生威胁,也是肝硬化、肝癌及肝脏相关死亡的主要原因[2]。在早期阶段(最近获得的感染)实施诊断与治疗有助于减少持续传播,尤其是在关键人群中;WHO 设定了到 203 年将新发 HCV 感染减少 90%、相关死亡率减少 65% 的消除目标,支持尽早控制 HCV 传播的公共卫生策略[2]。此外,早期阶段(近期获得性 HCV 感染)患者中约 50–70% 会进展为慢性感染(定义为病毒血症持续超过 6 个月),强调了对新近感染者进行及时干预以阻断继续传播的必要性[2]。
目前尚无获批的预防性丙型肝炎疫苗可供使用[1]。公共卫生层面的防控依赖于严格执行标准预防措施、推广减害策略以及倡导安全性行为[1]。在病毒清除后维持持续的监测随访,有助于降低进一步的病毒传播风险[1]。
- 1Liu CH et al. Acute hepatitis C virus infection: clinical update and remaining challenges. Clin Mol Hepatol. 2023 Jul. PMID: 36800699. doi: 10.3350/cmh.2022.0349.PubMed: https://pubmed.ncbi.nlm.nih.gov/36800699/
- 2Fasano M et al. Acute Hepatitis C: Current Status and Future Perspectives. Viruses. 2024 Nov 6. PMID: 39599853. doi: 10.3390/v16111739.PubMed: https://pubmed.ncbi.nlm.nih.gov/39599853/
- B17.1
- 1E50.2
数据覆盖
报告国家和地区
各报告国家的趋势
月度变化趋势
研究雷达
近期相关研究
Sex-specific burdens of acute hepatitis B and C and their attributable risk factors in 204 countries and territories, 1990-2021.
Tropical medicine and health
文献链接仅用于发现研究,不会改变或验证上方的监测序列。
数据获取
本页面数据索引,含来源链接和更新信息。
官方数据来源机构、频率与说明12
Australia NINDSS
Australia
Australian national notifiable diseases surveillance dashboard.
Australia NINDSS — Australian Capital Territory
Australian Capital Territory, Australia
Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.
Australia NINDSS — New South Wales
New South Wales, Australia
Australian NINDSS monthly state/territory notifications for New South Wales, kept separate from the Australia national aggregate.
Australia NINDSS — Northern Territory
Northern Territory, Australia
Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Queensland
Queensland, Australia
Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.
Australia NINDSS — Tasmania
Tasmania, Australia
Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.
Australia NINDSS — Victoria
Victoria, Australia
Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.
Australia NINDSS — Western Australia
Western Australia, Australia
Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.
Singapore CDA Weekly Infectious Diseases Bulletin
Singapore
Singapore national weekly case notifications, combining the official data.gov.sg 2012–2022 CSV history with CDA annual workbooks from 2023 onward; 2023 weekly PDFs are retained as a source fallback.
Taiwan, China CDC NIDSS
Taiwan, China
Taiwan, China monthly notifiable infectious disease open-data CSV feed.
US CDC NNDSS
United States
CDC National Notifiable Diseases Surveillance System provisional data.
US CDC NHSS HIV
United States
CDC NNDSS weekly data plus NHSS annual national HIV diagnoses