炭疽是由炭疽芽胞杆菌(Bacillus anthracis),即形成芽胞的革兰氏阳性菌引起的一种感染性疾病,部分病例也可由蜡样芽胞杆菌炭疽生物型导致。[1][2] 该菌在不利条件下形成高度耐受的芽胞,能在土壤或动物产品中长期存活,并可在宿主体内萌发后产生炭疽毒素作为主要毒力因子。[1][2]
疾病概览
细菌性炭疽
Anthrax
炭疽是由炭疽芽胞杆菌(Bacillus anthracis)或蜡样芽胞杆菌炭疽生物型(Bacillus cereus biovar anthracis)引起的人畜共患细菌性传染病,芽胞在不利环境下可长期存活并通过皮肤、吸入或胃肠道途径侵入人体。[1][2] 临床上主要表现为皮肤型、吸入型、胃肠型和注射型四种形式,潜伏期从一天到两个月不等,典型皮肤损害为无痛性黑色焦痂溃疡。[1] 高风险人群包括接触动物或动物制品者以及军事人员,可通过疫苗接种和暴露后抗生素预防来降低发病风险。[1][2]
阅读完整临床与流行病学资料6
症状通常在感染后一天至两个月之间出现,临床表现因感染途径不同而分为多种形式。[1] 皮肤型表现为局部小水疱伴周围肿胀,常发展为无痛性、中心黑色的溃疡;吸入型表现为发热、胸痛和呼吸困难;胃肠型表现为腹泻(可带血)、腹痛、恶心和呕吐;注射型症状类似皮肤型但常缺乏黑色焦痂,并可深入肌肉且扩散更快,因而更难以识别和治疗。[1]
2009年12月,苏格兰格拉斯哥和斯特灵地区的注射海洛因使用者中暴发了炭疽疫情,导致14人死亡,是英国自1960年以来首次记录到的非职业性人间炭疽暴发。[1] 疫情源头被认为与阿富汗地区海洛因被骨粉稀释有关。[1] 由于炭疽芽胞在环境中长期存活的特性,该病在曾发生过疫情的地区具有持续存在和再次暴发的风险。[1]
炭疽主要通过接触被炭疽芽胞污染的土壤或动物产品而传播,芽胞可通过皮肤破损、吸入或经口途径进入宿主,分别引起皮肤型、吸入型和胃肠道炭疽;注射型则见于被污染的注射物质。[1][2] 炭疽通常不会在人与人之间直接传播。[1] 对于疑似携带炭疽的死亡病例,应采取严格的隔离与防护措施,包括使用密封尸袋并进行焚烧,以防止芽胞传播。[1]
在高风险人群中推荐接种炭疽疫苗,目前已有BioThrax和CYFENDUS等获FDA批准的疫苗用于预防该病。[1][2] 在曾发生过动物疫情的地区,建议对动物进行免疫接种以从源头控制传播。[1] 暴露后可使用环丙沙星、左氧氟沙星或多西环素等进行约两个月的抗生素预防性治疗。[1][2]
- 1Wikipedia contributors. Anthrax - Wikipedia [Internet]. Wikipedia. cited 3 Sept 2026.Available from: https://en.wikipedia.org/wiki/Anthrax
- 2Sangwan N et al. Anthrax: Transmission, Pathogenesis, Prevention and Treatment. Toxins (Basel). 2025 Jan 24. PMID: 39998073. doi: 10.3390/toxins17020056.PubMed: https://pubmed.ncbi.nlm.nih.gov/39998073/
- 3Moayeri M et al. Anthrax Pathogenesis. Annu Rev Microbiol. 2015. PMID: 26195305. doi: 10.1146/annurev-micro-091014-104523.PubMed: https://pubmed.ncbi.nlm.nih.gov/26195305/
- 4Hammershaimb EAD et al. Vaccine Development. Pediatr Clin North Am. 2024 Jun. PMID: 38754940. doi: 10.1016/j.pcl.2024.01.018.PubMed: https://pubmed.ncbi.nlm.nih.gov/38754940/
- A22
- 1B91
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Periorbital anthrax after soil-contaminated trauma mimicking necrotizing infection: a case report with diagnostic and reconstructive challenges
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PCR-Based Detection of Priority Bacterial Biological Threat Agents: Advances in Diagnosis of Anthrax, Tularemia and Brucellosis
One Health Journal
Real-world analysis of depression-related adverse events associated with the adsorbed anthrax vaccine: integrating pharmacovigilance signals, machine learning risk prediction, and transcriptomic mechanisms
Infectious Diseases of Poverty
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PLOS Neglected Tropical Diseases
Distribution and Molecular Evolution of Bacillus anthracis Genotypes in Namibia
PLoS Neglected Tropical Diseases
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官方数据来源机构、频率与说明95
Austria AGES Radar for Infectious Diseases
Austria
AGES Radar monthly national source. Internal ingestion retains native categories; public release is disabled pending licence review.
Australia NINDSS
Australia
Australian national notifiable diseases surveillance dashboard.
Australia NINDSS — Australian Capital Territory
Australian Capital Territory, Australia
Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.
Australia NINDSS — New South Wales
New South Wales, Australia
Australian NINDSS monthly state/territory notifications for New South Wales, kept separate from the Australia national aggregate.
Australia NINDSS — Northern Territory
Northern Territory, Australia
Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Queensland
Queensland, Australia
Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.
Australia NINDSS — South Australia
South Australia, Australia
Australian NINDSS monthly state/territory notifications for South Australia, kept separate from the Australia national aggregate.
Australia NINDSS — Tasmania
Tasmania, Australia
Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.
Australia NINDSS — Victoria
Victoria, Australia
Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.
Australia NINDSS — Western Australia
Western Australia, Australia
Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.
ECDC Surveillance Atlas — Belgium Annual Baseline
Belgium
Belgium annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Bulgaria Annual Baseline
Bulgaria
Bulgaria annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Canada PHAC CNDSS Annual
Canada
Canada is the national jurisdiction; subdivision feeds are registered separately.
China CDC Weekly
China
Monthly notifiable infectious disease reports published by China CDC.
National Disease Control and Prevention Administration
China
Official China public health bulletin and query portal.
PubMed
China
Biomedical literature discovery feed used as supplementary context.
Public Health Science Data Center
Anhui, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Anhui, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Chongqing, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Chongqing, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Guangdong, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Guangdong, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Gansu, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Gansu, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Henan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Henan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Hebei, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Hebei, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Jilin, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Jilin, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Jiangsu, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Jiangsu, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Liaoning, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Liaoning, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Inner Mongolia, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Inner Mongolia, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Ningxia, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Ningxia, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Qinghai, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Qinghai, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Sichuan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Sichuan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shandong, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shandong, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shanghai, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shanghai, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shaanxi, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shaanxi, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shanxi, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shanxi, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Xinjiang, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Xinjiang, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Tibet, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Tibet, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Yunnan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Yunnan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Zhejiang, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Zhejiang, China
Province-level statutory infectious disease report published by the responsible health authority.
ECDC Surveillance Atlas — Cyprus Annual Baseline
Cyprus
Cyprus annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Czechia Annual Baseline
Czechia
Czechia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Germany RKI SurvStat 2.0
Germany
RKI SurvStat national weekly notification export; raw ZIP exports are retained and recent weeks are overwritten for revisions.
ECDC Surveillance Atlas — Denmark Annual Baseline
Denmark
Denmark annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Estonia Annual Baseline
Estonia
Estonia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Spain Annual Baseline
Spain
Spain annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Finland THL Infectious Diseases Register
Finland
Finland THL Infectious Diseases Register national monthly case counts. The current month is ingested as provisional and the latest three months are refreshed for source revisions.
ECDC Surveillance Atlas — France Annual Baseline
France
France annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — United Kingdom Annual Baseline
United Kingdom
United Kingdom annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Greece Annual Baseline
Greece
Greece annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Hong Kong, China CHP Notifiable Diseases
Hong Kong, China
Hong Kong, China CHP annual notifiable infectious disease CSVs normalized to national monthly totals
ECDC Surveillance Atlas — Croatia Annual Baseline
Croatia
Croatia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Hungary Annual Baseline
Hungary
Hungary annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Ireland HPSC Notifiable Diseases Hub
Ireland
Ireland HPSC national weekly notifiable-disease totals from the official ArcGIS FeatureServer. Internal ingestion is enabled; public release remains disabled pending written redistribution permission.
冰岛卫生署年度传染病看板
Iceland
冰岛全国分病种年度病例通报;历史值可能追溯修订,并保持年度总量口径。
冰岛卫生署性病监测看板
Iceland
实验室与登记监测的月度性病诊断事实;官方看板按季度发布。
冰岛卫生署呼吸道感染周度看板
Iceland
按 ISO 周记录的呼吸道疾病诊断数;住院、样本和疫苗指标不计入诊断数。
冰岛卫生署历史传染病登记
Iceland
1997—2021 年官方历史登记表,年度与月度事实按原始粒度保留。
冰岛卫生署历史 ICD 临床月报
Iceland
Saga 电子病历 ICD 就诊数;与登记通报不可比并保持独立。
ECDC Surveillance Atlas — Italy Annual Baseline
Italy
Italy annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
日本 NIID/JIHS 周报
Japan
日本 NIID/JIHS 周度传染病监测数据。
Korea KDCA EID
South Korea
Korea KDCA notifiable infectious disease OpenAPI or portal/KOSIS downloads aggregated to national monthly notification counts.
ECDC Surveillance Atlas — Liechtenstein Annual Baseline
Liechtenstein
Liechtenstein annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Lithuania Annual Baseline
Lithuania
Lithuania annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Luxembourg Annual Baseline
Luxembourg
Luxembourg annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Latvia Annual Baseline
Latvia
Latvia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Malta Annual Baseline
Malta
Malta annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Netherlands Annual Baseline
Netherlands
Netherlands annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Norway FHI MSIS Statistics Bank
Norway
Norway FHI MSIS national monthly notifications from the official Allvis frontend API; adapter contract checks guard the unversioned endpoint.
ECDC Surveillance Atlas — Poland Annual Baseline
Poland
Poland annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Portugal Annual Baseline
Portugal
Portugal annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Romania Annual Baseline
Romania
Romania annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
Sweden Public Health Agency SmiNet
Sweden
Sweden SmiNet national monthly reported cases from the official Public Health Agency statistics pages; public release is enabled with closed-month publication and revisable recent-month refreshes.
ECDC Surveillance Atlas — Slovenia Annual Baseline
Slovenia
Slovenia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
ECDC Surveillance Atlas — Slovakia Annual Baseline
Slovakia
Slovakia annual Member-State reported case counts from the ECDC Surveillance Atlas. Missing topic/year cells remain unknown and published zeroes are preserved. Data provided by ECDC based on data reported by EU/EEA Member States.
US CDC NNDSS
United States
CDC National Notifiable Diseases Surveillance System provisional data.
US CDC NHSS HIV
United States
CDC NNDSS weekly data plus NHSS annual national HIV diagnoses