伤寒是一种由肠道沙门氏菌伤寒血清型（S. Typhi）引起的侵袭性细菌性疾病，通过粪-口途径传播，导致全身性感染和发热性疾病[1]。
疾病概览
细菌性伤寒
Typhoid fever
有证据支持的资料英文 6/7 个适用章节 · 中文 6/7 个适用章节更新于 2026年9月3日
伤寒是一种侵袭性细菌性疾病，与菌血症相关，在非洲和亚洲造成高疾病负担[1]。伤寒主要影响从婴儿到青年人群[1]。病原体沙门氏菌肠道亚种伤寒血清型通过粪-口途径传播，穿过肠上皮播散至全身和细胞内部位，引起非特异性发热性疾病[1]。自2017年以来，在定义伤寒及抗菌药物耐药性的全球负担、理解疾病发病机制和免疫保护（通过对照人体感染研究）以及通过多家伙伴战略合作和高发地区靶向临床试验推进有效疫苗接种项目方面取得了显著进展[1]。
阅读完整临床与流行病学资料7
伤寒表现为非特异性发热性疾病[1]。伤寒沙门氏菌具有独特的毒力因子，包括参与症状发生的伤寒毒素和参与免疫逃避的Vi荚膜抗原[2]。
伤寒在非洲和亚洲造成高疾病负担，主要影响从婴儿到青年人群[1]。
伤寒通过粪-口途径传播，病原体穿过肠上皮并播散至全身和细胞内部位[1]。
通过战略多家伙伴合作和高发地区靶向临床试验，推进了有效疫苗接种项目[1]。
GlobalID 来源数据说明： 德语“Typhus”和“Typhus abdominalis”指伤寒，并非立克次体性斑疹伤寒。各国来源可能分别报告仅伤寒、仅副伤寒或二者合计；比较或汇总前必须保留并核对原始来源标签。
- 1Meiring JE et al. Typhoid fever. Nat Rev Dis Primers. 2023 Dec 14. PMID: 38097589. doi: 10.1038/s41572-023-00480-z.PubMed: https://pubmed.ncbi.nlm.nih.gov/38097589/
- 2Carey ME et al. Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes. Elife. 2023 Sep 12. PMID: 37697804. doi: 10.7554/eLife.85867.PubMed: https://pubmed.ncbi.nlm.nih.gov/37697804/
- 3Johnson R et al. Typhoidal Salmonella: Distinctive virulence factors and pathogenesis. Cell Microbiol. 2018 Sep. PMID: 30030897. doi: 10.1111/cmi.12939.PubMed: https://pubmed.ncbi.nlm.nih.gov/30030897/
数据覆盖
报告国家和地区
各报告国家的趋势
月度变化趋势
研究雷达
近期相关研究
Efektivitas Penggunaan Obat Antibiotik pada Pasien Demam <i>Typhoid</i>
Pharmaceutical Journal
Prioritizing the introduction of new vaccine in Tanzania (2026–2030): a multi-criteria decision analysis by the Tanzania immunization technical advisory group
Vaccine
Azithromycin with or without cefixime for suspected or culture-confirmed uncomplicated typhoid fever in Nepal, Bangladesh, and Pakistan (ACT-South Asia): a double-blind, parallel-group, randomised, placebo-controlled, phase 4 trial
The Lancet Infectious Diseases
Effectiveness of the TYPHIBEV® (Vi-CRM197 conjugate) vaccine introduction in Nepal: A test-negative, case-control study
Journal of Infection
Genomic epidemiology and antimicrobial resistance reveal local transmission dynamics of enteric fever in Shenzhen, one of the mega cities in China
Journal of Infection
显示 9 篇相关论文中的 5 篇。
文献链接仅用于发现研究，不会改变或验证上方的监测序列。
数据获取
本页面数据索引，含来源链接和更新信息。
官方数据来源机构、频率与说明22
Australia NINDSS
Australia
Australian national notifiable diseases surveillance dashboard.
Australia NINDSS — Australian Capital Territory
Australian Capital Territory, Australia
Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Northern Territory
Northern Territory, Australia
Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Queensland
Queensland, Australia
Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.
Australia NINDSS — South Australia
South Australia, Australia
Australian NINDSS monthly state/territory notifications for South Australia, kept separate from the Australia national aggregate.
Australia NINDSS — Tasmania
Tasmania, Australia
Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.
Australia NINDSS — Victoria
Victoria, Australia
Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.
Australia NINDSS — Western Australia
Western Australia, Australia
Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.
Brazil DATASUS SINAN
Brazil
Brazil Ministry of Health DATASUS/SINAN public DBC microdata aggregated to national monthly notification counts.
Canada PHAC CNDSS Annual
Canada
Canada is the national jurisdiction; subdivision feeds are registered separately.
Public Health Ontario IDTO Monthly
Ontario, Canada
Ontario-level current-year preliminary monthly case counts from Public Health Ontario's IDTO report.
Finland THL Infectious Diseases Register
Finland
Finland THL Infectious Diseases Register national monthly case counts. The current month is ingested as provisional and the latest three months are refreshed for source revisions.
Hong Kong, China CHP Notifiable Diseases
Hong Kong, China
Hong Kong, China CHP annual notifiable infectious disease CSVs normalized to national monthly totals
日本 NIID/JIHS 周报
Japan
日本 NIID/JIHS 周度传染病监测数据。
Korea KDCA EID
South Korea
Korea KDCA notifiable infectious disease OpenAPI or portal/KOSIS downloads aggregated to national monthly notification counts.
Norway FHI MSIS Statistics Bank
Norway
Norway FHI MSIS national monthly notifications from the official Allvis frontend API; adapter contract checks guard the unversioned endpoint.
New Zealand PHF Science Monthly Notifiable Diseases
New Zealand
PHF Science (formerly ESR) monthly notifiable disease surveillance data via internal globalID2 crawler
Sweden Public Health Agency SmiNet
Sweden
Sweden SmiNet national monthly reported cases from the official Public Health Agency statistics pages; public release is enabled with closed-month publication and revisable recent-month refreshes.
Singapore CDA Weekly Infectious Diseases Bulletin
Singapore
Singapore national weekly case notifications, combining the official data.gov.sg 2012–2022 CSV history with CDA annual workbooks from 2023 onward; 2023 weekly PDFs are retained as a source fallback.
Taiwan, China CDC NIDSS
Taiwan, China
Taiwan, China monthly notifiable infectious disease open-data CSV feed.
US CDC NNDSS
United States
CDC National Notifiable Diseases Surveillance System provisional data.
US CDC NHSS HIV
United States
CDC NNDSS weekly data plus NHSS annual national HIV diagnoses