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Peer reviewedOpen accessArboviral diseasesChikungunyaDengue

Internists facing emerging arboviral diseases: time to get prepared

Internal and Emergency Medicine·

Emanuele Durante-Mangoni, Augusto Delle Femine, Raffaella Gallo, Ciro di Gennaro, Agnès Lefort des Ylouses, Jose Manuel Ramos-Rincon, Fausto Roxo, Michael Samarkos, Miriam Stegemann

DOI
10.1007/s11739-026-04498-5
PMID
PMCID
OpenAlex
Study type
Journal article
Publisher
Springer Science and Business Media LLC
Article type
journal-article
Integrity
current

Why this research matters now

Environmental shifts and increased human mobility are extending arboviral range into new territories, necessitating heightened clinical awareness. The authors note that aligning bedside evaluation with laboratory standards and community prevention strategies enhances overall disease control efforts.

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Structured evidence summary

Research question

The article examines how physicians can identify and manage emerging arthropod-borne viral infections amid changing geographic patterns. It addresses the need for updated clinical strategies to handle undifferentiated febrile presentations.

Study design

The authors produced a narrative review compiling existing literature on arboviral characteristics and treatment protocols.

Population and setting

The discussion centers on individuals seeking care for unexplained fever in hospital-based internal medicine and emergency departments, as well as communities experiencing expanded arboviral circulation.

Main findings

While many infections remain mild or asymptomatic, severe manifestations including neurological damage, hemorrhagic events, and persistent joint pain can develop. Laboratory confirmation is often hindered by vague initial symptoms, variable test sensitivity over time, and immunological overlap between related viruses. Current patient care prioritizes rapid clinical assessment, appropriate testing windows, supportive measures, and preventive interventions due to the absence of targeted antiviral drugs.

Public-health relevance

Environmental shifts and increased human mobility are extending arboviral range into new territories, necessitating heightened clinical awareness. The authors note that aligning bedside evaluation with laboratory standards and community prevention strategies enhances overall disease control efforts.

Important limitations

The manuscript functions as a narrative review rather than a systematic analysis or primary data study. Diagnostic uncertainty stemming from symptom overlap and assay limitations further constrains definitive clinical classification.

GIDS interpretation

This work frames arboviral disease readiness as a core competency for internal medicine practitioners navigating evolving transmission landscapes. It provides a reference point for understanding how clinical observation and reporting mechanisms may adapt to broader ecological and demographic changes.

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Related GIDS surveillance

Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.

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Evidence relationships

This article has 11 auditable classifier relationships to diseases, places, topics, and study design.

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