Evaluation of immunogenicity and efficacy of a Plasmodium vivax nanoparticle vaccine in mice
Vaccine·
- DOI
- 10.1016/j.vaccine.2026.128857
- PMID
- 42322682
- PMCID
- —
- OpenAlex
- W7165376833
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The adaptable architecture of this delivery mechanism supports future development of combined immunizations targeting multiple vivax malaria components, aligning with broader disease control objectives.
Structured evidence summary
Research question
The investigation examines whether a tailored nanoparticle carrier displaying Plasmodium vivax circumsporozoite protein alongside a toll-like receptor activator can stimulate protective immune responses in rodents.
Study design
A preclinical trial employing BALB/c mice to measure vaccine-triggered antibody production and evaluate defense against genetically modified parasites through both cellular assays and live animal exposures.
Population and setting
Laboratory mice of the BALB/c strain functioned as the exclusive biological subjects for assessing the experimental immunization approach.
Main findings
Delivery of the nanoparticle formulation generated elevated antibody concentrations that successfully blocked parasite entry into liver cells during laboratory testing and provided limited defense against direct exposure in living animals.
Public-health relevance
The adaptable architecture of this delivery mechanism supports future development of combined immunizations targeting multiple vivax malaria components, aligning with broader disease control objectives.
Important limitations
Dependence on a single rodent species and artificial infection models restricts direct translation to human populations and natural environmental conditions.
GIDS interpretation
This record contributes methodological context regarding alternative antigen presentation systems for vivax malaria, enabling literature tracking without suggesting active epidemiological monitoring.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.