Characteristics of successful and unsuccessful strategies to increase vaccine intention and improve vaccine uptake for U.S. adult populations in the Affordable Care Act era (2010-2025): a systematic review and meta-regression
Vaccine·
- DOI
- 10.1016/j.vaccine.2026.128910
- PMID
- 42430872
- PMCID
- —
- OpenAlex
- W7167884539
- Study type
- Systematic review
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Highlights how logistical and organizational modifications can address persistent immunization gaps even after financial barriers are removed.
Structured evidence summary
Research question
Identifies which intervention approaches successfully enhance immunization intent and administration rates among American adults following recent healthcare policy shifts.
Study design
Functions as a peer-reviewed systematic review and meta-regression that applied PRISMA 2020 standards, dual reviewer screening, and GRADE certainty evaluations.
Population and setting
Encompasses American adult cohorts participating in influenza and coronavirus immunization initiatives across various administrative environments.
Main findings
Network-based recruitment and clinical service enhancements correlated with increased immunization participation. Emergency-period on-site distribution models showed reduced association with participation metrics. Collaborative frameworks consistently yielded superior engagement outcomes compared to isolated messaging efforts.
Public-health relevance
Highlights how logistical and organizational modifications can address persistent immunization gaps even after financial barriers are removed.
Important limitations
Authors acknowledge low to moderate certainty levels and emphasize requirements for more rigorous, equity-oriented investigations. This evaluation depends entirely on the provided abstract and metadata, necessitating the full manuscript for comprehensive analytical verification.
GIDS interpretation
Serves as a reference point for understanding historical intervention patterns within academic literature repositories. Cataloging this work aids contextual tracking of strategy evolution without indicating active epidemiological monitoring.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.