Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species
Nature Communications·
- DOI
- 10.1038/s41467-018-03949-8
- PMID
- 29654279
- PMCID
- PMC5899146
- OpenAlex
- W2797381074
- Study type
- Genomic study
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The work underscores the necessity of incorporating genetic sequencing tools across all phases of resistance tracking and control strategies.
Structured evidence summary
Research question
The investigation seeks to understand how antimicrobial resistance emerges and spreads within bacterial populations by examining concurrent outbreak patterns.
Study design
Researchers conducted a genomic epidemiology analysis focusing on parallel outbreak events.
Population and setting
The analysis focused on infection clusters occurring among men who have sex with men.
Main findings
Repeated exchange of a specific resistance plasmid accelerated ongoing outbreaks and triggered new ones. In contrast, infections linked to chromosomally inherited resistance markers showed more gradual growth. These results indicate that plasmid-mediated gene exchange significantly shapes outbreak trajectories for key resistant bacteria.
Public-health relevance
The work underscores the necessity of incorporating genetic sequencing tools across all phases of resistance tracking and control strategies.
Important limitations
The provided summary relies exclusively on the supplied single-article abstract and metadata, requiring access to the full manuscript for comprehensive evaluation and decision-grade interpretation.
GIDS interpretation
This publication addresses themes related to antimicrobial resistance and genomic epidemiology, which may aid in literature discovery and contextual mapping. It does not establish connections to any active monitoring networks or real-time data feeds.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.