Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
npj Vaccines·
- DOI
- 10.1038/s41541-023-00769-w
- PMID
- 37925544
- PMCID
- PMC10625542
- OpenAlex
- W4388339641
- Study type
- Journal article
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The work is relevant to One Health approaches, as RVF causes livestock abortion storms and fetal loss as well as severe human syndromes such as hemorrhagic fever, encephalitis, and retinitis, and continues to threaten endemic regions.
Structured evidence summary
Research question
The review surveys the historical development of Rift Valley fever (RVF) vaccines and considers prospects for next-generation candidates applicable to both humans and animals.
Study design
The article is a peer-reviewed narrative review summarizing existing RVF vaccine literature and candidate pipelines; no original empirical study design is described.
Population and setting
The review addresses RVF-endemic regions, including parts of Africa, Madagascar, the Comoros, Saudi Arabia, and Yemen, covering both livestock ruminants and human populations at risk of zoonotic transmission.
Main findings
Several veterinary RVF vaccines are already licensed in endemic countries, whereas no human RVF vaccine is currently licensed. The review identifies next-generation vaccine candidates as promising avenues for further development in both human and animal use.
Public-health relevance
The work is relevant to One Health approaches, as RVF causes livestock abortion storms and fetal loss as well as severe human syndromes such as hemorrhagic fever, encephalitis, and retinitis, and continues to threaten endemic regions.
Important limitations
This summary is limited to the supplied single-article abstract and bibliographic metadata; the original paper is required for decision-grade interpretation of methodology, candidate-specific evidence, and any explicit limitations.
GIDS interpretation
The article is discoverable through GIDS classifiers linking it to Rift Valley fever, related hemorrhagic fevers, several endemic countries, and One Health and vaccination topics; no link to a live surveillance signal is made here.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.