Clinical manifestations and laboratory findings in patients coinfected with dengue virus and SARS-CoV-2: a systematic review
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-026-13752-2
- PMID
- 42286517
- PMCID
- —
- OpenAlex
- W7164480836
- Study type
- Systematic review
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Documenting overlapping pathological features aids healthcare providers in recognizing complex presentations and justifies sustained clinical vigilance during suspected dual exposures.
Structured evidence summary
Research question
The investigation seeks to characterize the symptomatic and biochemical profiles associated with concurrent dengue virus and SARS-CoV-2 infections.
Study design
A PRISMA-compliant systematic review aggregating data from fifteen eligible publications, including case reports, series, cohort analyses, and theoretical discussions.
Population and setting
A pooled cohort of sixty-five individuals experiencing simultaneous viral exposure, extracted from literature published between 2020 and 2025.
Main findings
Aggregated observations highlight common occurrences of elevated temperature, gastrointestinal distress, dermatological reactions, and hemodynamic instability. Biochemical evaluations additionally documented altered leukocyte distributions and respiratory rate variations, though these metrics function as descriptive tallies rather than epidemiological prevalence rates.
Public-health relevance
Documenting overlapping pathological features aids healthcare providers in recognizing complex presentations and justifies sustained clinical vigilance during suspected dual exposures.
Important limitations
The underlying dataset consists predominantly of uncontrolled observational accounts lacking comparison groups, which precludes reliable assessments of prognostic outcomes or comparative illness severity. Substantial reporting heterogeneity further limits analytical robustness.
GIDS interpretation
The compiled observations establish an initial reference framework for potential diagnostic consideration, while explicitly acknowledging that current outputs remain exploratory and necessitate rigorously controlled investigations before broader application.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.