Reemergence of yellow fever virus in southeastern Brazil, 2017–2018: What sparked the spread?
PLOS Neglected Tropical Diseases·
- DOI
- 10.1371/journal.pntd.0010133
- PMID
- 35130278
- PMCID
- PMC8853510
- OpenAlex
- W4225435581
- Study type
- Journal article
- Publisher
- Public Library of Science (PLoS)
- Article type
- journal-article
- Integrity
- current
Publication version
This article has a linked preprint
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Open linked preprint →Why this research matters now
Findings highlight drought and rural or outdoor exposure as plausible contributors to YFV reemergence in southeastern Brazilian states that had been YFV-free for nearly a century, underscoring environmental and demographic factors relevant to outbreak preparedness.
Structured evidence summary
Research question
The study evaluated environmental drivers behind the 2017–2018 yellow fever virus reemergence in southeastern Brazil.
Study design
An ecological and spatiotemporal analysis combining human and non-human primate surveillance data from the Brazilian Ministry of Health with the monthly Standardized Precipitation Evapotranspiration Index, demographic review of cases, and a mechanistic conceptual framework linking drought to transmission.
Population and setting
Confirmed human and non-human primate YFV cases across four southeastern Brazilian states, with the epidemic originating in rural northern Minas Gerais and spreading into more urban southeastern states.
Main findings
Human and NHP cases were first detected in a hot, dry, rural area of northern Minas Gerais before spreading southeast into cooler, wetter urban states. Outbreaks coincided with drought in all four southeastern states, including an extreme drought in Minas Gerais. Confirmed cases showed higher odds of being male, working age, and reporting recent travel. The authors propose a “Mono-DrY” mechanistic framework linking drought to amplification of YFV transmission at the rural–urban interface.
Public-health relevance
Findings highlight drought and rural or outdoor exposure as plausible contributors to YFV reemergence in southeastern Brazilian states that had been YFV-free for nearly a century, underscoring environmental and demographic factors relevant to outbreak preparedness.
Important limitations
No explicit limitations are stated in the supplied abstract; this summary is limited to the supplied single-article abstract and metadata and should be supplemented with the original paper before drawing decision-grade conclusions.
GIDS interpretation
The paper sits within GIDS topics of surveillance, outbreak investigation, transmission dynamics, and climate/environment, and is indexed for Yellow fever in Brazil; this metadata describes the article’s discoverability scope only and does not, by itself, constitute a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.