Fatal Yellow Fever in Travelers to Brazil, 2018
MMWR. Morbidity and Mortality Weekly Report·
- DOI
- 10.15585/mmwr.mm6711e1
- PMID
- 29565840
- PMCID
- PMC5868208
- OpenAlex
- W2789909988
- Study type
- Journal article
- Publisher
- Centers for Disease Control MMWR Office
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The report underscores the importance of pre-travel yellow fever vaccination for travelers to outbreak-affected regions in Brazil, where the case fatality rate among those with severe illness ranges from 20% to 60%.
Structured evidence summary
Research question
This report describes fatal yellow fever cases among international travelers returning from Brazil during the 2018 outbreak.
Study design
Case series of travel-related yellow fever infections identified through international surveillance following the Brazilian outbreak that began in December 2016.
Population and setting
Ten international travelers returning from Brazil between January 2018 and the report date, none of whom had received yellow fever vaccination prior to travel.
Main findings
Among 10 unvaccinated travelers who developed yellow fever after visiting Brazil, four died. Cases were linked to an outbreak affecting São Paulo, Minas Gerais, and Rio de Janeiro states, prompting expanded vaccination recommendations in January 2018.
Public-health relevance
The report underscores the importance of pre-travel yellow fever vaccination for travelers to outbreak-affected regions in Brazil, where the case fatality rate among those with severe illness ranges from 20% to 60%.
Important limitations
This summary relies on the supplied single-article abstract and bibliographic metadata. Full interpretation of case ascertainment methods, clinical details, and travel exposure histories requires the complete published report.
GIDS interpretation
The article is discoverable through yellow fever, Brazil, outbreak investigation, travel medicine, and vaccination classifiers. It documents travel-associated cases during a recognized Brazilian yellow fever outbreak rather than signaling a new or unrecognized event.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.