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Geographic evidence hub

Canada research

Published infectious-disease research classified with a high-confidence geographic relationship to Canada.

Published evidence
19
Diseases
14
Countries
3
Topics
12

Evidence stream

Published literature

19

19 publications

Using high frequency GPS data to assess wintering goose proximity to commercial poultry facilities on the Delmarva peninsula for avian influenza risk management and surveillance.

Hardy MJ, Williams CK, Ladman BS +8 more

PloS one

Type
Journal article
Scope
Canada, United States

Why it matters nowThe findings describe a possible way to prioritize biosecurity or surveillance resources around poultry facilities using observed wintering-waterfowl presence. This is an evidence-context signal from the supplied article and does not establish that the ranking method is validated for current surveillance or outbreak prediction.

Peer reviewedOpen accessInvasive pneumococcal disease
DOI 10.1016/j.vaccine.2026.128977 ↗

Clinical features and outcomes of pediatric breakthrough invasive pneumococcal disease (IPD) in vaccinated children in Calgary, Alberta, Canada, 2003–2024

Emily J. Doucette, Leah J. Ricketson, Luis Murguía-Favela +2 more

Vaccine

Type
Journal article
Scope
Canada

Why it matters nowThe article is relevant to pediatric pneumococcal vaccine programs because it describes vaccine-type invasive disease occurring despite vaccination and identifies serotypes highlighted in the abstract as prominent among breakthrough cases.

Emergence of alveolar echinococcosis in Canada: a warning for the USA

Stephen D. Vaughan, Jamie L. Rothenburger, Kinga Kowalewska-Grochowska

Current Opinion in Infectious Diseases

Type
Journal article
Scope
Canada, United States

Why it matters nowThe authors describe alveolar echinococcosis as an emerging, under-recognized zoonotic disease in Canada and emphasize that early recognition using Em-specific diagnostics, along with a One Health approach integrating human, veterinary, and wildlife data, is needed to reduce morbidity and mortality.

Lessons from Ontario’s COVID-19 Vaccination Strategies: Implications for Preventing Measles Resurgence in Canada

Stella Triboi, Fatih Sekercioglu

Pandemics

Type
Journal article
Scope
Canada

Why it matters nowThe paper addresses the critical public health challenge of measles resurgence in a country that previously achieved elimination. It explores how lessons from pandemic vaccination efforts might inform strategies to restore and maintain routine immunization coverage.

Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: A retrospective cohort study from Alberta, Canada

Sylvia Aponte-Hao, Huong Luu, Karen J. B. Martins +13 more

PLOS One

Type
Cohort study
Scope
Canada

Why it matters nowThe findings can inform decision-making, public health strategies, and policy development to protect vaccinated populations at elevated risk. The results support recommendations from Canada's National Advisory Committee on Immunisation for specific groups to remain current with COVID-19 vaccination to reduce severe outcomes.

2024/25 end-of-season KP.2 vaccine effectiveness against COVID-19 hospitalization in older adults: a test-negative study in Quebec, Canada

Sara Carazo, Danuta M. Skowronski, Chantal Sauvageau +3 more

Vaccine

Type
Journal article
Scope
Canada

Why it matters nowThe findings demonstrate that KP.2 vaccine provides meaningful but short-lived protection against COVID-19 hospitalization in older adults, informing vaccination timing and booster strategies for this vulnerable population.

mRNA COVID-19 vaccine safety in adults from the Canadian national vaccine safety network

Matthew P. Muller, Phyumar Soe, Hennady P. Shulha +12 more

Vaccine

Type
Cohort study
Scope
Canada

Why it matters nowThe findings provide Canadian adult vaccine-safety evidence on short-term health events following two-dose mRNA vaccination and include comparison with an unvaccinated group. The abstract describes symptom frequency and healthcare-utilization outcomes but does not establish longer-term effects or causality.

Understanding the low effectiveness of influenza vaccines in older adults of South Korea: an exploration of contributing factors

Joon Young Song, Hee Jin Cheong

Vaccine

Type
Journal article
Scope
South Korea, Canada, United States

Why it matters nowThe article highlights a coverage–effectiveness paradox in older adults and outlines candidate policy and platform-level strategies to improve influenza vaccine outcomes in South Korea, with potential global relevance.

Revaccination of individuals with cardiac adverse events following COVID-19 vaccination: A Canadian Immunization Research Network study

Pierre-Philippe Piché-Renaud, C. Arianne Buchan, Catherine Burton +11 more

Vaccine

Type
Journal article
Scope
Canada

Why it matters nowFindings inform clinical guidance on revaccination after cardiac AEFIs, suggesting revaccination may be considered for chest pain not meeting myocarditis criteria while indicating caution for adults with prior myopericarditis.

Peer reviewedOpen accessSyphilisCongenital syphilisTreatmentOutbreak investigation
DOI 10.1093/cid/ciaf651 ↗

Evaluating the Impact of Implementing and Scaling-Up the Use of Syphilis Rapid/Point-of-Care Tests: An Interrupted Time Series Analysis of New Syphilis Positivity Rates in Alberta, Canada

L Alexa Thompson, Jennifer Gratrix, Noel Ives +16 more

Clinical Infectious Diseases

Type
Journal article
Scope
Canada

Why it matters nowRapid point-of-care testing enables same-day treatment for individuals in nontraditional settings, addressing barriers to testing and treatment among key populations. The intervention was associated with significant declines in new syphilis positivity rates in a high-income setting experiencing resurgence of heterosexual syphilis transmission.

Peer reviewedOpen accessSyphilisInfectious syphilisTreatmentDiagnostics
DOI 10.1186/s12879-025-12263-w ↗

Evaluating the MedMira Multiplo® Complete Syphilis (TP/nTP) antibody test in a sexually transmitted infection clinic in Ottawa, Canada: increased rapid diagnosis and improved antibiotic stewardship

Patrick O’Byrne, Riley Dillabough, Kathleen Whyte +4 more

BMC Infectious Diseases

Type
Journal article
Scope
Canada

Why it matters nowAccelerated diagnostic workflows may streamline clinical decision-making and support antimicrobial stewardship by clarifying infection status prior to therapeutic decisions.

Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions

Emily Howerton, Thomas C. Williams, Jean-Sébastien Casalegno +7 more

Nature Communications

Type
Mathematical modelling
Scope
Canada, South Korea

Why it matters nowFindings provide a modeling foundation for anticipating possible hMPV dynamics when RSV immunization strategies are deployed.

Cost-Effectiveness of Antiviral Drugs to Prevent or Treat Influenza A, Influenza B, or Zoonotic Influenza

Ilke Akpinar, Dagmara Chojecki

Canadian Journal of Health Technologies

Type
Journal article
Scope
Canada

Why it matters nowAssessing the economic performance of antiviral regimens aids decision-makers in optimizing budget distribution for seasonal outbreaks and emergency preparedness. Recognizing financially sustainable treatment pathways supports long-term healthcare system resilience against emerging viral threats.

Measles in Canada: modelling outbreaks with variable vaccine coverage and interventions

Jennifer McNichol, Javad Valizadeh, Samara Chaudhury +1 more

BMC Infectious Diseases

Type
Journal article
Scope
Canada

Why it matters nowThe work is positioned as a downstream tool that translates global measles activity into local Canadian outbreak projections of duration and size, with potential utility for informing public communication about measles-related risk.

Chikungunya vaccine development, challenges, and pathway toward public health impact

Clara Maure, Kanat Khazhidinov, Hyolim Kang +9 more

Vaccine

Type
Journal article
Scope
Canada, United States

Why it matters nowThe article is relevant to decisions about chikungunya vaccine introduction, financing, manufacturing scale-up, equitable distribution, and demand generation in at-risk populations. It identifies evidence on disease burden and vaccination impact as important inputs for such decisions.

A wastewater-based epidemic model for SARS-CoV-2 with application to three Canadian cities

Shokoofeh Nourbakhsh, Aamir Fazil, Michael Li +13 more

Epidemics

Type
Journal article
Scope
Canada

Why it matters nowThe paper describes wastewater surveillance combined with modelling as a potential complementary source for estimating epidemiological measures when interpreting clinical and wastewater signals together. The abstract states that this approach may support broader assessment of epidemic conditions, but it does not establish performance for operational public-health decisions.

Cost-effectiveness of Latent Tuberculosis Infection Screening before Immigration to Low-Incidence Countries

Jonathon R. Campbell, James C. Johnston, Victoria J. Cook +3 more

Emerging Infectious Diseases

Type
Journal article
Scope
Canada

Why it matters nowThe findings are positioned as evidence to inform policy decisions on preimmigration LTBI screening for migrants to low-incidence countries, alongside further research on sustainability, acceptability, and program implementation.

Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019

Danuta M Skowronski, Siobhan Leir, Suzana Sabaiduc +11 more

Eurosurveillance

Type
Journal article
Scope
Canada

Why it matters nowThe findings document substantial seasonal influenza vaccine protection against the predominant circulating strain during the 2018/19 season, with particular relevance for young children who experienced disproportionate disease burden.

Foodborne Botulism in Canada, 1985–2005

Daniel Leclair, Joe Fung, Judith L. Isaac-Renton +8 more

Emerging Infectious Diseases

Type
Journal article
Scope
Canada

Why it matters nowThe findings highlight persistent foodborne botulism risk associated with traditional food preparation practices in specific indigenous populations and underscore the importance of early diagnosis and treatment in reducing mortality. Sporadic outbreaks linked to commercial and restaurant foods indicate broader surveillance needs.