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Disease evidence hub

Malaria

A curated view of published Malaria research, auditable classifier relationships, and its publication timeline.

Published evidence
481
Diseases
68
Countries
97
Topics
14

Evidence timeline

Publication timeline

Open disease surveillance →

Monthly publication counts from the catalogue show how research activity changes over time.

24 publication months · peak 2026-10 (31)
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Research Radar publications

Guidance and policy markers identify dated publications in the curated catalogue; they do not by themselves establish that an official policy changed on that date.

Evidence stream

Published literature

481

30 of 481 publications shown

Absence of Plasmodium falciparum Histidine-Rich Protein 2 and 3 (Pfhrp2/3) Gene Deletions in Rizal, Palawan, the Philippines

Jennifer S. Luchavez, Alison Paolo N. Bareng, Freya Spencer +6 more

The American Journal of Tropical Medicine and Hygiene

Type
Journal article
Scope
Philippines

Why it matters now The findings are relevant to malaria elimination in the Philippines: the authors suggest that molecular monitoring of pfhrp2 deletions in routine surveillance could improve assessment of RDT performance and support elimination strategies targeting 2030.

Peer reviewed Open access Malaria Treatment
DOI 10.1128/aac.00382-26 ↗

Anti-plasmodial activity of proteasome inhibitors against various Plasmodium species: a preclinical evaluation

Nguyen Van Truong, Tuyet-Kha Nguyen, Nguyen Sy Thau +9 more

Antimicrobial Agents and Chemotherapy

Type
Journal article
Scope
Not classified

Why it matters now The results identify proteasome inhibitors as potential antimalarial drug candidates in the context of increasing drug resistance and support further investigation of their structure, dosing, and combination regimens. The evidence is preclinical and does not establish clinical efficacy or safety.

Peer reviewed Open access MalariaPlasmodium falciparum malaria Transmission dynamicsTreatment
DOI 10.1128/aac.00434-26 ↗

Modeling the potential effect of cabamiquine-pyronaridine for chemoprevention against Plasmodium falciparum malaria

Lucy C. Okell, Perrine Courlet, Filippo Venezia +4 more

Antimicrobial Agents and Chemotherapy

Type
Mathematical modelling
Scope
Not classified

Why it matters now If further clinical evaluation supports the modeled performance, the single-dose regimen could address barriers associated with multi-day treatment and potentially support less frequent seasonal chemoprevention cycles while maintaining impact.

Status of Malaria Vaccine Introduction—Africa, 2019–2024

Anh N. Ly, Jenny A. Walldorf, Mary J. Hamel +5 more

The American Journal of Tropical Medicine and Hygiene

Type
Journal article
Scope
Ghana, Kenya, Malawi

Why it matters now The abstract identifies malaria vaccine introduction as an opportunity to integrate vaccination with preventive health services intended to reduce childhood morbidity and mortality.

Association of housing quality and altitude with malaria infection among school-aged children in mainland Tanzania

Mbaraka John Remiji, Felista Mwingira, Gerald Kiwelu +4 more

BMC Public Health

Type
Cross-sectional study
Scope
Tanzania

Why it matters now The authors suggest that context-specific housing and environmental measures could complement established malaria interventions, particularly in marginalized rural communities.

Peer reviewed MalariaPlasmodium falciparum malaria Treatment
DOI 10.4269/ajtmh.26-0364 ↗

Recurrent Plasmodium falciparum Malaria after Delayed Hemolysis Induced by Artemether–Lumefantrine

Kosuke Asano, Tokio Hoshina, Tomomi Miyamoto +5 more

The American Journal of Tropical Medicine and Hygiene

Type
Journal article
Scope
Philippines, Togo

Why it matters now The report supports consideration of follow-up for at least four weeks after artemether–lumefantrine because delayed hemolysis and recrudescence may occur.

Peer reviewed Open access Malaria Transmission dynamics
DOI 10.1038/s41467-026-77156-1 ↗

The CCCH-type zinc-finger PfMD3 promotes translation for malaria parasite transmission

Riëtte van Biljon, Suyash Bhatnagar, Rajat Kumar +8 more

Nature Communications

Type
Journal article
Scope
Not classified

Why it matters now The findings are relevant to malaria transmission research because they connect a parasite regulatory protein with gamete fertility and mosquito infectivity. The supplied abstract does not evaluate human outcomes, prevention measures, treatments, or intervention effectiveness.

Projecting potential population exposure to the invasive malaria vector Anopheles stephensi

Yelin Sun, Weihang Liu, Yuanyuan Jing +5 more

Environmental Research Letters

Type
Journal article
Scope
Not classified

Why it matters now The projected expansion of vector habitat and population exposure may increase the geographic context in which malaria control is needed, supporting region-specific approaches that address population and environmental influences together.

A genomic toolkit for surveillance and elimination of the principal malaria vectors in Southeast Asia.

Tristan P.W. Dennis, Amelie Vantaux, Kevin C Kobylinski +14 more

Wellcome Open Research

Type
Journal article
Scope
Bangladesh, Cambodia, Thailand

Why it matters now The toolkit is presented as a foundation for genomic surveillance to inform vector control and malaria elimination in Southeast Asia, where vector diversity and insecticide resistance complicate control.

Peer reviewed Open access Malaria Health policy
DOI 10.37284/eajass.9.4.6163 ↗

Perceived Policy Appropriateness as an Interpretive Mechanism of Citizen Compliance: Toward an Integrated Framework for Malaria Control Policy Implementation in Uganda

Wilfred Opobo, James Mugisha, Madinah Nabukeera

East African Journal of Arts and Social Sciences

Type
Journal article
Scope
Uganda

Why it matters now The findings underscore contextual and interpretive influences on voluntary uptake of malaria control guidance, offering considerations for implementation scholarship.

Peer reviewed Open access Malaria DiagnosticsTreatment
DOI 10.1016/j.bios.2026.118956 ↗

A novel capillary-driven dual-mode imaging flow cytometry system for malaria parasite detection and quantification

Suraj K. Maurya, Matt Stark, Alexander Martin Küenzi +4 more

Biosensors and Bioelectronics

Type
Journal article
Scope
Not classified

Why it matters now Malaria disproportionately affects resource-limited tropical and subtropical regions where skilled microscopy operators may be scarce. A low-cost, automated diagnostic tool could reduce dependence on operator expertise and support more consistent parasitemia monitoring in such settings.

Strengthening capacity in high-burden malaria-endemic countries: a strategic analysis of training gaps and blended learning solutions in national malaria control programs

Moses Alikali, Graham V. Brown, Samira H. Abdelrahman +1 more

Malaria Journal

Type
Journal article
Scope
Not classified

Why it matters now Authors conclude that targeted capacity building through blended methods is considered essential to improve service delivery and pursuit of elimination goals.

From social media engagement to public health action: the role of social media in sustainable malaria elimination

Xun Zheng, Gelin Huang

Frontiers in Public Health

Type
Journal article
Scope
China, India

Why it matters now Results suggest social media analytics could augment conventional malaria surveillance and community engagement, but should not replace dedicated elimination efforts.

Peer reviewed Open access Malaria Treatment
DOI 10.1038/s41467-026-78985-w ↗

A combinatorial genetics approach reveals limits to redundancy within Plasmodium falciparum invasion ligand families

Eleanor Silvester, Anna Kuroshchenkova, Carla Briggs +4 more

Nature Communications

Type
Journal article
Scope
Not classified

Why it matters now The authors propose that PfEBA175, PfRh2b and PfRh4 may form a critical nexus of the invasion machinery and that combinatorial targeting of these ligands could be a beneficial therapeutic approach. This is a proposed therapeutic implication, not evidence of clinical or surveillance impact.

Peer reviewed Open access Malaria DiagnosticsTreatment
DOI 10.67260/hsd.v27i11.7954 ↗

Portage Asymptomatique de Plasmodium chez les Parturientes à Bouaké, Côte d'Ivoire : Une Étude Transversale de 200 Cas

Tamboura MTA, Dou GSP, Nassoue DMO +8 more

HEALTH SCIENCES AND DISEASE

Type
Cross-sectional study
Scope
Cote d'Ivoire

Why it matters now Silent infection among delivering women is present at the site, supporting calls to reinforce ITN and IPT use; more sensitive molecular methods are advised for future work.

Jatropha curcas-derived curcusones B and C inhibit Plasmodium falciparum with preferential activity against late-ring and early-trophozoite stages

Moussa Abba Garba Abba, Mariscal Brice Tchatat Tali, Kevine Johanne Jumeta Dongmo +7 more

Frontiers in Malaria

Type
Journal article
Scope
Not classified

Why it matters now The compounds are presented as early hit candidates that may help diversify malaria treatment options amid drug-resistance challenges, pending further development.

Peer reviewed Open access Malaria Transmission dynamics
DOI 10.1093/g3journal/jkag302 ↗

De novo assembly of complete Plasmodium falciparum isolate genomes using PacBio HiFi sequencing technology

Prince B Nyarko, Mathieu Quenu, Marc-Antoine Guéry +8 more

G3: Genes, Genomes, Genetics

Type
Journal article
Scope
Gambia

Why it matters now The assemblies offer a genomic resource for research on parasite evolution, transmission, and antigenic diversity in malaria-endemic settings.

Household Water, Sanitation and Malaria Infection among Children Aged 6–59 Months in Kogi State, Nigeria: A Secondary Analysis of the 2015 Nigeria Malaria Indicator Survey

Adenike Abigail Orebanjo, Aminat Omolara Lasisi, Obhioze Augustine Akpoka +2 more

International Journal of Global Health and Epidemiology

Type
Cross-sectional study
Scope
Nigeria

Why it matters now A considerable malaria burden exists among young children in Kogi State. Combined prevention and environmental-health actions plus larger local studies were suggested by the authors.

Characterization of the Gametocytocidal and Putative Transmission-Blocking Activity of Chlorotonil A Against Plasmodium falciparum

Thomas Martin Schäfer, Lais Pessanha de Carvalho, Linn Kruse +13 more

Pharmaceutics

Type
Journal article
Scope
Gabon

Why it matters now The compound may support development of a treatment that also curbs malaria transmission, based on the reported dual activity.

Peer reviewed Open access MalariaPlasmodium vivax malaria VaccinationTransmission dynamicsVaccine effectiveness
DOI 10.1371/journal.pntd.0014810 ↗

Transgenic Plasmodium berghei expressing P. vivax pre-erythrocytic antigens SSP3 and SPECT1 to elucidate their efficacy towards vaccine development

Surendra Kumar Kolli, Pradeep Annamalai Subramani, Jai Ramesar +8 more

PLOS Neglected Tropical Diseases

Type
Journal article
Scope
Not classified

Why it matters now The work addresses the need for improved P. vivax vaccines, since CSP-based approaches offer limited protection and dormant hypnozoites drive relapse and transmission; pre-erythrocytic antigens could prevent clinical malaria from primary and relapse infections.

Peer reviewed Open access Malaria SurveillanceTreatment
DOI 10.1186/s12879-026-14529-3 ↗

Unraveling antimalarial resistance in Plasmodium vivax in Southeast Asia: from molecular markers to phenotypic and clinical evidence—A scoping review

Nisa Fauziah, Puji Budi Setia Asih, Bachti Alisjahbana +6 more

BMC Infectious Diseases

Type
Journal article
Scope
Cambodia, Myanmar, Malaysia

Why it matters now The work highlights fragmented resistance evidence and the need for integrated molecular, phenotypic, and therapeutic monitoring to clarify clinical impact in the region.

Bayesian spatio-temporal modeling of childhood anemia in Tanzania: spatial distribution, determinants, and causal impact of malaria

Lembris Laanyuni Njotto, Wilfred Senyoni, Angelina Mageni Lutambi

Frontiers in Public Health

Type
Journal article
Scope
Tanzania

Why it matters now Results support geographically targeted, multisectoral action that joins malaria control with social, economic, and environmental measures for childhood anemia.

Peer reviewed Open access Malaria Treatment
DOI 10.1038/s41467-026-78536-3 ↗

Sevuparin in children with severe malaria: a phase I safety and dose-finding trial

Mike Chaponda, Jonathan Gwasupika, Roisin Connon +10 more

Nature Communications

Type
Journal article
Scope
Not classified

Why it matters now High mortality from severe malaria in African children motivates adjunctive agents; this trial supports further study of sevuparin dosing.

Peer reviewed Open access COVID-19Dengue Surveillance
DOI 10.1371/journal.pntd.0014745 ↗

Temporal trends in reported vector-borne diseases in China before and after the onset of COVID-19 from 2004 to 2023

Zhiqun Lei, Qianying Liu, Zhixin Lei

PLOS Neglected Tropical Diseases

Type
Journal article
Scope
China

Why it matters now The work underscores the need for dependable disease reporting during emergencies and adaptable forecasting to aid vector-borne disease control in China.

Epidemiology of malaria in the Torres Strait Islands, Australia, 2000-2025 and the public health response to three recent outbreaks

C Bowers, D Pourmarzi, J Hanson +9 more

Communicable Diseases Intelligence

Type
Journal article
Scope
Australia, Papua New Guinea

Why it matters now Local risk persists due to high PNG incidence and treaty-related movement. Continued cross-border collaboration and stronger surveillance are needed to limit importation of malaria and other pathogens.

Non-genetic red blood cell variability can modulate hemoglobin consumption by intracellular Plasmodium falciparum

Joseph R. Perko, Abhyudai Singh, Secilia I. Lopez +9 more

mSystems

Type
Mathematical modelling
Scope
Not classified

Why it matters now Accounting for host cell heterogeneity may improve within-host growth predictions and refine timing of hemoglobin-dependent antimalarial use, with possible relevance to other intracellular infections.

Salivary Plasmodium falciparum histidine-rich protein 2 levels are poor predictors of parasite density and clinical malaria status in patients with acute uncomplicated malaria in Chulaimbo, western Kenya

Ruth Awuor Omingo, Cyrus Ayieko, Patrick Ogola Onyango +3 more

Parasites, Hosts and Diseases

Type
Journal article
Scope
Kenya

Why it matters now Salivary PfHRP2 appears weak for predicting infection metrics here, though more sensitive saliva assays might later aid diagnosis and treatment guidance.

An integrated approach to prioritizing areas for imported malaria re-establishment prevention in Chongqing, China

Dan Jiang, Yan Tan, Mengping Yang +7 more

Frontiers in Cellular and Infection Microbiology

Type
Journal article
Scope
Chongqing, China, Democratic Republic of the Congo, Nigeria

Why it matters now The prioritized district map can support targeted surveillance and vector control during peak season to reduce re-establishment risk from imported parasites.

Detection of Plasmodium vivax and Plasmodium falciparum using colorimetric loop-mediated isothermal amplification from dried blood spots collected in active and passive malaria surveillance in the Peruvian Amazon

Oscar Nolasco, Joaquín Gómez, Hugo Rodríguez-Ferrucci +2 more

PLOS Neglected Tropical Diseases

Type
Journal article
Scope
Not classified

Why it matters now The assay may serve as a sensitive complementary option for malaria surveillance in low-transmission and elimination contexts, especially where low-density infections evade microscopy.