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Disease evidence hub

Malaria

A curated view of published Malaria research, auditable classifier relationships, and the available GIDS surveillance timeline.

Published evidence
113
Diseases
46
Countries
54
Topics
13

Evidence timeline

Surveillance activity and publication volume

Open disease surveillance →
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GIDS reported recordsResearch Radar publications

The two bars use independent scales. Their alignment supports navigation and comparison only; it does not claim that publication activity explains surveillance activity.

Guidance and policy markers identify dated publications in the curated catalogue; they do not by themselves establish that an official policy changed on that date.

Evidence stream

Published literature

113

30 of 113 publications shown

Built for the village, breached in the city: redesigning malaria vector control for Anopheles stephensi and insecticide resistance

Shyamkumar Sriram

Frontiers in Malaria

Type
Commentary
Scope
Not classified

Why it matters nowThe piece argues that vector control requires fundamental redesign to address urban transmission and insecticide resistance. It reviews next-generation nets with dual active ingredients, urban larval source management, and surveillance needs, emphasizing that entomological and resistance surveillance capacity is threatened by donor financing contraction.

Multiple local PfDHFR I164L haplotype expansions drive Plasmodium falciparum antifolate resistance in Uganda

Victor Asua, Karamoko Niaré, Shreeya Garg +16 more

Nature Communications

Type
Journal article
Scope
Uganda

Why it matters nowThe findings are relevant to malaria control because the studied mutations are associated with antifolate resistance, and the paper describes PfDHFR I164L as conferring higher pyrimethamine resistance. The results indicate that resistance-related patterns may vary across locations using sulfadoxine-pyrimethamine chemoprevention.

Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment

Joana Laranjinha, Andréa Luciana S. da Silva, Sara B. Lopes +7 more

International Journal of Infectious Diseases

Type
Journal article
Scope
Not classified

Why it matters nowThe co-occurrence of resistance-associated markers and treatment failure in one patient is presented as justification for ongoing genomic surveillance of antimalarial resistance.

Artemisinin partial resistance at a crossroads: evidence for continental variation in Plasmodium falciparum clearance phenotypes

Varun Hosangadi, David A Fidock

The Lancet Infectious Diseases

Type
Journal article
Scope
Not classified

Why it matters nowApplying southeast Asia-derived clearance thresholds in Africa may obscure early signals of artemisinin partial resistance and delay policy responses, supporting the need for region-specific surveillance criteria.

Molecular identification and phylogenetic analysis of Anopheles mosquitoes from malaria endemic-areas of Limpopo Province, South Africa

Mzwandile Thabani Hadebe, Samson Anjikwi Malgwi, Moses Okpeku

The Journal of Basic and Applied Zoology

Type
Genomic study
Scope
South Africa

Why it matters nowThe findings indicate that molecular testing may complement morphological identification in mosquito vector monitoring in the reported Limpopo setting. The abstract states that using additional, more variable markers alongside morphology could improve species discrimination and support malaria-control programmes.

Biological Activity of Artemisia mexicana: Antimalarial, Immunomodulatory, and Antioxidant Effects in Experimental Malaria

Monserrat Sofía López-Padilla, Luis Antonio Cervantes-Candelas, Jesús Aguilar-Castro +5 more

International Journal of Molecular Sciences

Type
Journal article
Scope
Not classified

Why it matters nowThe findings suggest that Artemisia mexicana may offer therapeutic potential by addressing multiple pathogenic mechanisms in malaria, including parasite burden, immune dysregulation, and oxidative stress. These effects could inform future phytotherapeutic approaches, though human efficacy and safety data are required.

Peer reviewedOpen accessMalariaTreatment
DOI 10.3389/fimmu.2026.1862560 ↗

Multi-platform evidence of GSDMD-dependent pyroptosis in malaria with a potential role for TLR7

Yumei Gong, Yiwei Liu, Longkun Li +10 more

Frontiers in Immunology

Type
Journal article
Scope
Not classified

Why it matters nowThe study addresses macrophage-associated inflammation in malaria and identifies TLR7-mediated regulation of pyroptosis as a potential area for further investigation.

Peer reviewedOpen accessMalariaDiagnostics
DOI 10.3389/fmed.2026.1911275 ↗

Deep learning–assisted malaria microscopy with sensitivity-aware threshold optimization

Fatma Dehbi, Reda Mohamed Hamou, Menaouer Brahami +4 more

Frontiers in Medicine

Type
Journal article
Scope
Not classified

Why it matters nowThe work addresses a clinically meaningful failure mode of malaria microscopy—missed parasitized erythrocytes—and proposes a sensitivity-aware thresholding strategy that could reduce false negatives in screening workflows.

The effect of mefloquine dose on outcome of uncomplicated falciparum malaria treated with artesunate-mefloquine: a WWARN systematic review and individual patient data meta-analysis

Elizabeth A. Ashley, Emmanuel Baron, Marielle K. Bouyou-Akotet +43 more

Malaria Journal

Type
Systematic review
Scope
Not classified

Why it matters nowThe results indicate that while the regimen remains effective, age-specific tolerability issues may constrain dosing adjustments in young children.

Plasmodium thiamine pyrophosphokinase is essential for sporozoite formation and activation of an antiplasmodial thiamine analogue

Imam Fathoni, Ümit Y. Kina, Alex H. Y. Chan +10 more

Proceedings of the National Academy of Sciences

Type
Journal article
Scope
Not classified

Why it matters nowTPK plays a critical role in sporogony within the mosquito vector, supporting its potential as a transmission-blocking target for antimalarial intervention.

Peer reviewedOpen accessMalariaVaccination
DOI 10.1038/s41467-026-77069-z ↗

Dynamic hinge-motion of PfRIPR revealed by malaria invasion inhibitory antibodies

Brendan Farrell, Andrew J. R. Cooper, Egle Butkeviciute +4 more

Nature Communications

Type
Journal article
Scope
Not classified

Why it matters nowThe findings may inform the design of vaccine immunogens based on PfRIPR and improve understanding of structural changes involved in erythrocyte invasion. The abstract does not provide evidence about effects in populations, vaccine effectiveness, or public-health outcomes.

Land-Use and Bakin Birji Pond Dynamics in Relation to Climate Variability and Malaria Seasonality in Zinder Region, Niger

B. Hamadou Younoussa, A. Moussa Issaka, L. Mahaman Moustapha +2 more

Current Journal of Applied Science and Technology

Type
Journal article
Scope
Niger

Why it matters nowThe article provides local context on hydro-landscape change, climate measures, and seasonal malaria counts in one Nigerien setting. It identifies a need for finer environmental monitoring and longer, population-standardised malaria time series to evaluate temporal and causal relationships.

FEBRILE ILLNESS, MALARIA TEST POSITIVITY, AND BREAKTHROUGH INFECTION AMONG CHILDREN UNDER FIVE DURING SEASONAL MALARIA CHEMOPREVENTION IN PLATEAU STATE, NIGERIA: A RETROSPECTIVE ANALYSIS OF ROUTINE HEALTH FACILITY DATA, 2024

Michael Idoko Abah, Ishaku Akyala Adamu, Samson Coker Olasukanmi +2 more

International Journal of Biomedical Research and Innovations

Type
Journal article
Scope
Andorra, Nigeria

Why it matters nowRoutine monitoring highlights persistent diagnostic confirmation rates alongside widespread intervention coverage, indicating a need for enhanced programmatic tracking and periodic efficacy assessments.

Rethinking malaria seasonality: humidity-driven transmission shifts and emerging hotspots in Zambia (2009–2023)

Therese Shema Nzayisenga, Nyuma Mbewe, Kelvin Mwangilwa +12 more

Frontiers in Tropical Diseases

Type
Journal article
Scope
Zambia

Why it matters nowShifting environmental drivers necessitate updated operational approaches that prioritize flexible resource allocation and incorporate environmental monitoring into routine disease management frameworks.

Peer reviewedOpen accessEbolaMalariaTreatmentDiagnostics
DOI 10.3389/fmed.2026.1848720 ↗

Challenges in managing ruptured ectopic pregnancy complicated by hemorrhagic shock in an Ebola treatment unit in DR Congo: first reported case

Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka +11 more

Frontiers in Medicine

Type
Journal article
Scope
Democratic Republic of the Congo

Why it matters nowThe case indicates that obstetric emergencies can arise in Ebola treatment units and that limited diagnostic, surgical, anesthetic, and referral capacity may complicate timely care. The authors conclude that such units should have capacity to diagnose and manage obstetric complications in addition to providing Ebola-related care.

Peer reviewedOpen accessPlasmodium falciparum malariaMalariaTransmission dynamicsDiagnostics
DOI 10.3389/fmala.2026.1875477 ↗

Retrospective study of association between Plasmodium falciparum malaria density and platelet count at Presbyterian Hospital, Agogo

Theophilus Arthur-Gyimah, Doreen Asantewa Abeasi, Frank Bediako Agyei +2 more

Frontiers in Malaria

Type
Journal article
Scope
Ghana

Why it matters nowRoutine hematology analyzers may provide a swift, objective mechanism to prioritize suspected cases and streamline patient flow in settings where conventional parasitological testing encounters operational barriers.

Heterogeneity of use, access, and retention of insecticide-treated nets: Implications for subnational tailoring to maximise malaria control

Andrew C Glover, Hannah Koenker, El Hadji Amadou Niang +2 more

eLife

Type
Journal article
Scope
Burkina Faso, United Kingdom, Ghana

Why it matters nowThe findings indicate that subnational variation in net use after access may be relevant when considering malaria-control deployment strategies. The abstract describes a framework for using routinely collected data to support subnational programme tailoring.

Peer reviewedMalariaPlasmodium falciparum malariaTreatmentSurveillanceTravel medicine
DOI 10.1093/cid/ciag456 ↗

Extending the Duration of Artemether-Lumefantrine Treatment for Uncomplicated Plasmodium falciparum Malaria: Updated US Centers for Disease Control and Prevention Guidance Based on Review of Surveillance, Consultations, and Published Data

Jimee Hwang, Eric S Halsey, Mateusz M Plucinski +9 more

Clinical Infectious Diseases

Type
Meta-analysis
Scope
United States

Why it matters nowThe article provides evidence relevant to treatment policy for uncomplicated Plasmodium falciparum malaria among travelers in the United States. Its findings were reported as informing updated CDC guidance, but this summary does not independently assess that guidance or connect the article with a live surveillance signal.

Hidden burden of malaria in pregnancy in hard-to-reach areas of Odisha, India: challenges to elimination and the case for integrating molecular surveillance

Sonali Sandeepta, Ramakanta Rana, Jyoti Ghosal +8 more

Frontiers in Public Health

Type
Cross-sectional study
Scope
India

Why it matters nowUndetected parasitic carriage among expectant mothers complicates regional disease eradication initiatives. Integrating advanced diagnostic capabilities into routine antenatal monitoring could improve intervention targeting and support national health objectives.

Climate blind spots in malaria control: frontline perspectives on climate adaptation and malaria control in Zambia

Nyuma Mbewe, Therese Sherma Nzayisenga, Kelvin Mwangilwa +10 more

Frontiers in Tropical Diseases

Type
Cross-sectional study
Scope
Zambia

Why it matters nowIntegrating environmental monitoring into routine disease management protocols could enhance operational resilience during overlapping health emergencies. Developing targeted training modules on ecological risk assessment may improve how local teams adjust interventions to shifting conditions.

Field evaluation of SumiLarv™ 2MR larvicide for controlling the invasive malaria vector Anopheles stephensi in Ethiopia: a randomised controlled trial

Alemayehu Dagne, Patricia Doumbe-Belisse, Teshome Degefa +15 more

Malaria Journal

Type
Randomised controlled trial
Scope
Ethiopia

Why it matters nowThe findings suggest SumiLarv 2MR may be a suitable larval source management tool against the invasive urban-tolerant vector An. stephensi, which complicates existing malaria control in Ethiopia.

Peer reviewedOpen accessPlasmodium vivax malariaMalariaDiagnosticsTravel medicine
DOI 10.1007/s15010-026-02930-8 ↗

Delayed diagnosis of Plasmodium vivax malaria and associated factors among Thai patients and patients from neighboring countries at the Hospital for Tropical Diseases, Bangkok, Thailand

Sakarn Charoensakulchai, Noppadon Tangpukdee, Polrat Wilairatana +4 more

Infection

Type
Journal article
Scope
Thailand

Why it matters nowRecognizing these temporal barriers supports the development of region-specific awareness campaigns and triage guidelines for fever management in areas experiencing reduced transmission.

Peer reviewedOpen accessViral HepatitisMalariaVaccinationTreatment
DOI 10.1093/rescon/vmag135 ↗

Africa’s Silent Humanitarian Crisis: Why Viral Hepatitis Must No Longer Be Ignored

Danjuma Adda, C Wendy Spearman, Asgeir Johannessen +11 more

Research Connections

Type
Journal article
Scope
Egypt

Why it matters nowThe article positions viral hepatitis as an urgent public health priority warranting immediate action through expanded testing, diagnosis, treatment, birth-dose vaccination, and integration with Universal Health Coverage initiatives.

Peer reviewedMalariaPlasmodium falciparum malariaTransmission dynamics
DOI 10.1097/inf.0000000000005376 ↗

Malaria Transmission Via Needle Stick Injury: A Case Report and Systematic Review of the Literature.

Malek M, Rothensteiner M, Rumelhart F +8 more

The Pediatric infectious disease journal

Type
Systematic review
Scope
Not classified

Why it matters nowThe findings document rare but recognized occupational transmission risk for healthcare workers managing malaria patients, emphasizing the need for standard precautions and post-exposure protocols in clinical settings where malaria is encountered.

Peer reviewedOpen accessDengueMalariaDiagnosticsTreatment
DOI 10.3390/clinpract16080150 ↗

Severe Dengue and Dengue–Malaria Coinfection: A Case Series from a Referral Hospital in Montería, Colombia

Paula A. Avilés-Vergara, Dina Ricardo-Caldera, Osnamir Elias Bru-Cordero +4 more

Clinics and Practice

Type
Journal article
Scope
Colombia

Why it matters nowConcurrent illness presentation complicates clinical assessment in tropical zones, suggesting that healthcare systems require enhanced diagnostic triage and continuous patient observation strategies.

Generational selection, transcriptomics and functional characterization reveal the impact of environmental pollutants on the evolution of insecticide resistance in malaria vectors.

Muhammad A, Ibrahim SS, Irving H +4 more

Insect biochemistry and molecular biology

Type
Journal article
Scope
Not classified

Why it matters nowRelevant to malaria control because it addresses insecticide resistance in malaria vectors and suggests environmental pollutants may be part of the resistance context.

Experimental validation of a computationally designed mosquito midgut SGU protein-based epitope vaccine against malaria.

Singh H, Dahiya N, Kirar M +3 more

Developmental and comparative immunology

Type
Journal article
Scope
Not classified

Why it matters nowThe study is relevant to malaria prevention research because it explores a vaccine concept aimed at mosquito-parasite biology rather than treatment. It is an early-stage candidate described as needing further evaluation before any practical interpretation.

Phytochemical synergy in artemisia annua herbal tea against malaria: a systematic review of its efficacy and safety in the context of emerging Pfkelch13 resistance

Jérôme Munyangi wa Nkola, Pierre Akilimali Zalagile, Hendrick Lukuke Mbutshu +3 more

Infectious Diseases of Poverty

Type
Systematic review
Scope
Not classified

Why it matters nowThe pronounced difference between rapid initial clearance and prolonged parasitological failure positions the botanical infusion as a supplementary measure rather than a definitive monotherapy in endemic regions.

Longitudinal evidence of differential pertussis antibody durability following natural infection among vaccinated children living in contrasting malaria transmission settings in coastal Kenya

Mercy S. Safari, Elijah T. Gicheru, Maureen W. Mburu +9 more

Vaccine

Type
Journal article
Scope
Kenya

Why it matters nowPersistent malaria transmission may erode long-term humoral immunity to pertussis following natural infection, with potential implications for pertussis control strategies and booster vaccination scheduling in malaria-endemic regions.

Evaluation of immunogenicity and efficacy of a Plasmodium vivax nanoparticle vaccine in mice

Francis Babila Ntumngia, Surendra Kumar Kolli, Gregory P. Howard +12 more

Vaccine

Type
Journal article
Scope
Not classified

Why it matters nowThe adaptable architecture of this delivery mechanism supports future development of combined immunizations targeting multiple vivax malaria components, aligning with broader disease control objectives.