病毒性肝炎是一个涵盖性术语,指由肝炎病毒引起的肝脏炎症性疾病,可表现为自限性过程,也可进展为纤维化(瘢痕形成)、肝硬化或肝癌[1][2]。全球约3.04亿人携带乙型或丙型肝炎,但大多数人仍无法获得检测和治疗机会[1]。
疾病概览
病毒性肝炎
Viral Hepatitis
病毒性肝炎是由多种传染性病毒和非传染性因素引起的肝脏炎症,可导致一系列健康问题,包括严重的肝损伤和癌症,部分病例可能致命[1][2]。主要有五种肝炎病毒类型,即甲型、乙型、丙型、丁型和戊型,它们在传播方式、疾病严重程度、地理分布和预防方法上存在重要差异[1][2]。其中乙型和丙型肝炎可在数亿人中导致慢性病,是肝硬化、肝癌和病毒性肝炎相关死亡的最常见原因,每年约造成130万人死亡[1][2]。
阅读完整临床与流行病学资料6
急性感染可能症状有限或无症状,也可能表现为黄疸(皮肤和眼睛发黄)、尿色深、极度疲劳、恶心、呕吐和腹痛等症状[2]。肝功能检查中,肝细胞损伤表现为天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)水平不成比例升高;胆汁淤积性损伤则表现为碱性磷酸酶水平不成比例升高[3]。ALT水平升高与肝脏相关死亡风险增加相关,男性正常上限约为29-33 IU/l,女性为19-25 IU/l[3]。
全球约3.04亿人携带乙型或丙型肝炎病毒,每年约造成130万人死亡,使其成为主要传染病杀手之一[1][2]。乙型和丙型肝炎在数亿人中导致慢性病,是肝硬化和肝癌的最常见原因[2]。世界卫生组织《2022-2030年全球卫生部门艾滋病、病毒性肝炎和性传播感染战略》设定了消除病毒性肝炎的明确目标,计划到2030年将新发感染降至52万例,肝炎相关死亡降至45万例,较2015年分别减少90%和65%[1]。然而,如不采取紧急持续行动,预计到2030年将新增950万例感染、210万例肝癌和280万例死亡[1]。
甲型和戊型肝炎通常通过摄入受污染的食物或水传播[2]。乙型、丙型和丁型肝炎通常经由接触感染者的体液传播,包括接收受污染的血液或血液制品、使用受污染设备进行侵入性医疗操作[2]。此外,乙型肝炎还可经由分娩时母婴传播、家庭成员间传播以及性接触传播[2]。
病毒性肝炎的预防策略包括:扩大乙型肝炎疫苗接种规模、改善乙型和丙型肝炎的预防、检测和治疗可及性,以及开展有针对性的公众教育宣传活动以提高意识和减少传播[1]。已有甲型、乙型和戊型肝炎的疫苗可用[4]。由于缺乏有效的抗病毒治疗,戊型肝炎对孕妇尤其危险,妊娠期急性甲型或戊型肝炎病毒感染对母婴健康构成最大风险[5]。
- 1World Health Organization. Hepatitis [Internet]. cited 1 Sept 2026.Available from: https://www.who.int/health-topics/hepatitis
- 2World Health Organization. Hepatitis [Internet]. cited 1 Sept 2026.Available from: https://www.who.int/news-room/questions-and-answers/item/hepatitis
- 3Odenwald MA et al. Viral hepatitis: Past, present, and future. World J Gastroenterol. 2022 Apr 14. PMID: 35582678. doi: 10.3748/wjg.v28.i14.1405.PubMed: https://pubmed.ncbi.nlm.nih.gov/35582678/
- 4Kwo PY et al. ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. Am J Gastroenterol. 2017 Jan. PMID: 27995906. doi: 10.1038/ajg.2016.517.PubMed: https://pubmed.ncbi.nlm.nih.gov/27995906/
- 5Terrault NA et al. Viral hepatitis and pregnancy. Nat Rev Gastroenterol Hepatol. 2021 Feb. PMID: 33046891. doi: 10.1038/s41575-020-00361-w.PubMed: https://pubmed.ncbi.nlm.nih.gov/33046891/
- B15-B19
- 1E50
数据覆盖
报告国家和地区
各报告国家的趋势
月度变化趋势
研究雷达
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显示 11 篇相关论文中的 5 篇。
文献链接仅用于发现研究,不会改变或验证上方的监测序列。
数据获取
本页面数据索引,含来源链接和更新信息。
官方数据来源机构、频率与说明75
Australia NINDSS
Australia
Australian national notifiable diseases surveillance dashboard.
Australia NINDSS — Australian Capital Territory
Australian Capital Territory, Australia
Australian NINDSS monthly state/territory notifications for Australian Capital Territory, kept separate from the Australia national aggregate.
Australia NINDSS — New South Wales
New South Wales, Australia
Australian NINDSS monthly state/territory notifications for New South Wales, kept separate from the Australia national aggregate.
Australia NINDSS — Northern Territory
Northern Territory, Australia
Australian NINDSS monthly state/territory notifications for Northern Territory, kept separate from the Australia national aggregate.
Australia NINDSS — Queensland
Queensland, Australia
Australian NINDSS monthly state/territory notifications for Queensland, kept separate from the Australia national aggregate.
Australia NINDSS — South Australia
South Australia, Australia
Australian NINDSS monthly state/territory notifications for South Australia, kept separate from the Australia national aggregate.
Australia NINDSS — Tasmania
Tasmania, Australia
Australian NINDSS monthly state/territory notifications for Tasmania, kept separate from the Australia national aggregate.
Australia NINDSS — Victoria
Victoria, Australia
Australian NINDSS monthly state/territory notifications for Victoria, kept separate from the Australia national aggregate.
Australia NINDSS — Western Australia
Western Australia, Australia
Australian NINDSS monthly state/territory notifications for Western Australia, kept separate from the Australia national aggregate.
China CDC Weekly
China
Monthly notifiable infectious disease reports published by China CDC.
National Disease Control and Prevention Administration
China
Official China public health bulletin and query portal.
PubMed
China
Biomedical literature discovery feed used as supplementary context.
Public Health Science Data Center
Anhui, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Anhui, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Beijing, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Beijing, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Chongqing, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Chongqing, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Fujian, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Fujian, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Guangdong, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Guangdong, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Gansu, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Gansu, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Guangxi, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Guangxi, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Guizhou, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Guizhou, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Henan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Henan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Hubei, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Hubei, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Hebei, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Hebei, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Hainan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Hainan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Heilongjiang, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Heilongjiang, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Hunan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Hunan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Jilin, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Jilin, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Jiangsu, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Jiangsu, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Jiangxi, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Jiangxi, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Liaoning, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Liaoning, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Inner Mongolia, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Inner Mongolia, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Ningxia, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Ningxia, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Qinghai, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Qinghai, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Sichuan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Sichuan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shandong, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shandong, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shanghai, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shanghai, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shaanxi, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shaanxi, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Shanxi, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Shanxi, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Tianjin, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Tianjin, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Xinjiang, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Xinjiang, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Tibet, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Tibet, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Yunnan, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Yunnan, China
Province-level statutory infectious disease report published by the responsible health authority.
Public Health Science Data Center
Zhejiang, China
Chinese province-level historical monthly observations; this higher-priority source overlays overlapping official monthly reports.
Provincial statutory infectious disease monthly report
Zhejiang, China
Province-level statutory infectious disease report published by the responsible health authority.
日本 NIID/JIHS 周报
Japan
日本 NIID/JIHS 周度传染病监测数据。